ICA1L_RAT
ID ICA1L_RAT Reviewed; 435 AA.
AC Q6RUG5;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Islet cell autoantigen 1-like protein;
DE AltName: Full=Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog;
DE AltName: Full=Ica69-related protein;
GN Name=Ica1l; Synonyms=Als2cr15;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=12682071; DOI=10.1074/jbc.m213222200;
RA Spitzenberger F., Pietropaolo S., Verkade P., Habermann B.,
RA Lacas-Gervais S., Mziaut H., Pietropaolo M., Solimena M.;
RT "Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated
RT with the Golgi complex of insulinoma INS-1 cells.";
RL J. Biol. Chem. 278:26166-26173(2003).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
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DR EMBL; AY491990; AAR36901.1; -; mRNA.
DR RefSeq; NP_955432.1; NM_199400.1.
DR AlphaFoldDB; Q6RUG5; -.
DR STRING; 10116.ENSRNOP00000045103; -.
DR iPTMnet; Q6RUG5; -.
DR PhosphoSitePlus; Q6RUG5; -.
DR PaxDb; Q6RUG5; -.
DR GeneID; 316432; -.
DR KEGG; rno:316432; -.
DR UCSC; RGD:735110; rat.
DR CTD; 130026; -.
DR RGD; 735110; Ica1l.
DR eggNOG; KOG3891; Eukaryota.
DR HOGENOM; CLU_037158_1_0_1; -.
DR InParanoid; Q6RUG5; -.
DR OrthoDB; 766523at2759; -.
DR PhylomeDB; Q6RUG5; -.
DR TreeFam; TF317186; -.
DR PRO; PR:Q6RUG5; -.
DR Proteomes; UP000002494; Unplaced.
DR Genevisible; Q6RUG5; RN.
DR GO; GO:0001669; C:acrosomal vesicle; ISO:RGD.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR GO; GO:0051049; P:regulation of transport; IBA:GO_Central.
DR GO; GO:0007286; P:spermatid development; ISO:RGD.
DR Gene3D; 1.20.1270.60; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR010504; AH_dom.
DR InterPro; IPR024114; Islet_autoAg_Ica1/Ica1-like.
DR InterPro; IPR006723; Islet_autoAg_Ica1_C.
DR PANTHER; PTHR10164; PTHR10164; 2.
DR Pfam; PF06456; Arfaptin; 1.
DR Pfam; PF04629; ICA69; 2.
DR SMART; SM01015; Arfaptin; 1.
DR SMART; SM01237; ICA69; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR PROSITE; PS50870; AH; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..435
FT /note="Islet cell autoantigen 1-like protein"
FT /id="PRO_0000076177"
FT DOMAIN 44..247
FT /note="AH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00294"
FT REGION 391..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 435 AA; 48645 MW; A1A9D12218123142 CRC64;
MDSFEHLRPE DSQSVVSRMQ KKYWKTKQVF IKATGKKEDE HVVASDAELD AKLEVFHSIQ
ETCNELVKAV EKYQLRLNVI SEEENELGLF LTFQAERDAT QAGKMMGAAG KALCSSAKQR
LALCTPLSRL KQEVATFSQR AISDTSVTIN RMERARTEYR GALLWMKDAS QELDPDTFKQ
VEKFRKVQIQ VRNSKDCFDK LKMDVCQKVD LLGASRCNML SHSLATYQRT LLGFWEKTAQ
MMSQIQEACA GFHPYDFMAL KQLQDTPGNL TAEDKEEQTE GSCLSTNLNK VALSEEEERF
EREPAVARAL PRDSLEGDDF EKEFSFLSSL LSPTSSRASE CTQECQPACG SPSLMCQEPS
LGPGPLTSSS QFLPSRLFDL GLHADGAFNS WASQEGSEHS DTLPVPSQHP KKLKYLGPLS
NPDAIGHSDD ELLNA
