ICA69_RAT
ID ICA69_RAT Reviewed; 480 AA.
AC Q63054; Q6P3W0;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Islet cell autoantigen 1;
DE AltName: Full=69 kDa islet cell autoantigen;
DE Short=ICA69;
DE AltName: Full=Islet cell autoantigen p69;
DE Short=ICAp69;
DE Short=p69;
GN Name=Ica1 {ECO:0000312|RGD:621465};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAA64909.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BB {ECO:0000312|EMBL:AAA64909.1}; TISSUE=Pancreatic islet;
RX PubMed=7918678; DOI=10.1016/0925-4439(94)90113-9;
RA Miyazaki I., Gaedigk R., Hui M.F., Cheung R.K., Morkowski J., Rajotte R.V.,
RA Dosch H.-M.;
RT "Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1
RT diabetes.";
RL Biochim. Biophys. Acta 1227:101-104(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-279.
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in neurotransmitter secretion.
CC {ECO:0000250|UniProtKB:P97411}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol. Golgi apparatus membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic
CC vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic
CC vesicle membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}. Note=Predominantly cytosolic. Also exists as a membrane-
CC bound form which has been found associated with synaptic vesicles and
CC also with the Golgi complex and immature secretory granules.
CC {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH63810.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; L20900; AAA64909.1; -; mRNA.
DR EMBL; BC063810; AAH63810.1; ALT_SEQ; mRNA.
DR PIR; I65309; I65309.
DR AlphaFoldDB; Q63054; -.
DR DIP; DIP-60171N; -.
DR IntAct; Q63054; 1.
DR STRING; 10116.ENSRNOP00000011651; -.
DR jPOST; Q63054; -.
DR PaxDb; Q63054; -.
DR PRIDE; Q63054; -.
DR UCSC; RGD:621465; rat.
DR RGD; 621465; Ica1.
DR eggNOG; KOG3891; Eukaryota.
DR InParanoid; Q63054; -.
DR PhylomeDB; Q63054; -.
DR PRO; PR:Q63054; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0030425; C:dendrite; IDA:RGD.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IDA:RGD.
DR GO; GO:0005795; C:Golgi stack; IDA:RGD.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
DR GO; GO:0030667; C:secretory granule membrane; ISS:UniProtKB.
DR GO; GO:0030672; C:synaptic vesicle membrane; ISS:UniProtKB.
DR GO; GO:0140090; F:membrane curvature sensor activity; ISO:RGD.
DR GO; GO:0019904; F:protein domain specific binding; IMP:RGD.
DR GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
DR GO; GO:0050796; P:regulation of insulin secretion; IEA:InterPro.
DR GO; GO:0043254; P:regulation of protein-containing complex assembly; IMP:RGD.
DR GO; GO:0051049; P:regulation of transport; IBA:GO_Central.
DR Gene3D; 1.20.1270.60; -; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR010504; AH_dom.
DR InterPro; IPR030796; ICA1.
DR InterPro; IPR024114; Islet_autoAg_Ica1/Ica1-like.
DR InterPro; IPR006723; Islet_autoAg_Ica1_C.
DR PANTHER; PTHR10164; PTHR10164; 1.
DR PANTHER; PTHR10164:SF3; PTHR10164:SF3; 1.
DR Pfam; PF06456; Arfaptin; 1.
DR Pfam; PF04629; ICA69; 2.
DR SMART; SM01015; Arfaptin; 1.
DR SMART; SM01237; ICA69; 1.
DR SUPFAM; SSF103657; SSF103657; 1.
DR PROSITE; PS50870; AH; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoplasmic vesicle; Golgi apparatus; Membrane;
KW Neurotransmitter transport; Reference proteome; Synapse; Transport.
FT CHAIN 1..480
FT /note="Islet cell autoantigen 1"
FT /id="PRO_0000084132"
FT DOMAIN 50..253
FT /note="AH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00294"
FT REGION 276..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..294
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 33..34
FT /note="KQ -> NE (in Ref. 1; AAA64909)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 480 AA; 54663 MW; ACF52032A93572F6 CRC64;
MSGHKCYSWE LQDRFAQDKS VVNKMQQKYW ETKQAFIKAT GKKEDEHVVA SDADLDAKLE
LFHSIQRTCL DLSKAIVLYQ KRICFLSQEE NELGKFLRSQ GFQDKTRAGK MMQATGKALC
FSSQQRLALR NPLCRFHQEV ETFRHRAISD TWLTVNRMEQ CRTEYRGALL WMKDVSQELD
PDLYKQMEKF RKVQTQVRLA KKNFDKLKMD VCQKVDLLGA SRCNLLSHML ATYQTTLLHF
WEKTSHTMAA IHESFKGYQP YEFTTLKSLQ DPMKKLVEKE KKKSSRRENR EAVAQEPRQL
ISLEEENQHK ESSTCQKEEG KSVPSSVDKS SADDACSGPI DELLDVKPEE ACLGPMAGTP
EPESGDKDDL LLLNEIFSTS SLDEGEFSRE WAAVFGDDRL KEPAPMGAQG EPDPKPQIGS
AFLPSQLLDQ NMKDLQASLQ EPAKAASDLT AWFSLFADLD PLSNPDAIGK TDKEHELLNA
