ID   ICAA_ASCSU              Reviewed;          65 AA.
AC   P19399;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Carboxypeptidase A inhibitor;
OS   Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6253;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2648995; DOI=10.1016/0003-9861(89)90017-9;
RA   Homandberg G.A., Litwiller R.D., Peanasky R.J.;
RT   "Carboxypeptidase inhibitors from Ascaris suum: the primary structure.";
RL   Arch. Biochem. Biophys. 270:153-161(1989).
CC   -!- FUNCTION: Inhibits carboxypeptidase A.
CC   -!- INTERACTION:
CC       P19399; P15085: CPA1; Xeno; NbExp=2; IntAct=EBI-15754788, EBI-1642148;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I44 family.
CC       {ECO:0000305}.
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DR   PIR; S03858; S03858.
DR   PDB; 3FJU; X-ray; 1.60 A; B=3-64.
DR   PDBsum; 3FJU; -.
DR   AlphaFoldDB; P19399; -.
DR   SMR; P19399; -.
DR   DIP; DIP-48698N; -.
DR   IntAct; P19399; 1.
DR   MEROPS; I44.001; -.
DR   EvolutionaryTrace; P19399; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR032767; ACI44.
DR   Pfam; PF15270; ACI44; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Metalloenzyme inhibitor;
KW   Metalloprotease inhibitor; Protease inhibitor; Secreted.
FT   CHAIN           1..65
FT                   /note="Carboxypeptidase A inhibitor"
FT                   /id="PRO_0000084133"
FT   HELIX           9..11
FT                   /evidence="ECO:0007829|PDB:3FJU"
FT   STRAND          17..19
FT                   /evidence="ECO:0007829|PDB:3FJU"
FT   TURN            20..23
FT                   /evidence="ECO:0007829|PDB:3FJU"
FT   STRAND          24..26
FT                   /evidence="ECO:0007829|PDB:3FJU"
FT   HELIX           28..38
FT                   /evidence="ECO:0007829|PDB:3FJU"
FT   HELIX           46..49
FT                   /evidence="ECO:0007829|PDB:3FJU"
FT   STRAND          52..54
FT                   /evidence="ECO:0007829|PDB:3FJU"
FT   STRAND          57..59
FT                   /evidence="ECO:0007829|PDB:3FJU"
FT   STRAND          61..63
FT                   /evidence="ECO:0007829|PDB:3FJU"
SQ   SEQUENCE   65 AA;  7511 MW;  E84DC9CA8326180B CRC64;
     DQVRKCLSDT DCTNGEKCVQ KNKICSTIVE IQRCEKEHFT IPCKSNNDCQ VWAHEKICNK
     LPWGL