ID   ICAC_STAAN              Reviewed;         350 AA.
AC   Q7A348;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Probable poly-beta-1,6-N-acetyl-D-glucosamine export protein;
DE            Short=PGA export protein;
DE            Short=Poly-beta-1,6-GlcNAc export protein;
DE   AltName: Full=Biofilm polysaccharide intercellular adhesin export protein;
DE            Short=Biofilm PIA export protein;
DE   AltName: Full=Intercellular adhesion protein C;
GN   Name=icaC; OrderedLocusNames=SA2462;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Presumably involved in the export of the biofilm adhesin
CC       polysaccharide poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also
CC       referred to as PIA) across the cell membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the acyltransferase 3 family. {ECO:0000305}.
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DR   EMBL; BA000018; BAB43767.1; -; Genomic_DNA.
DR   PIR; E90075; E90075.
DR   RefSeq; WP_000723836.1; NC_002745.2.
DR   AlphaFoldDB; Q7A348; -.
DR   EnsemblBacteria; BAB43767; BAB43767; BAB43767.
DR   KEGG; sau:SA2462; -.
DR   HOGENOM; CLU_064947_1_0_9; -.
DR   OMA; YHFYFVP; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   InterPro; IPR002656; Acyl_transf_3_dom.
DR   Pfam; PF01757; Acyl_transf_3; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..350
FT                   /note="Probable poly-beta-1,6-N-acetyl-D-glucosamine export
FT                   protein"
FT                   /id="PRO_0000208073"
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   350 AA;  41344 MW;  CA4BB4114B3C0596 CRC64;
     MKKIRLELVY LRAIICAIII ITHLLTQITL KHENMEGGSL VLQFYIRNIV IFGTPCFIIL
     SQLLTTLNYQ KVTYRYLTTR VKYILIPYIL MGLFYSYSES LLTDSSFNKQ FIENVLLGQW
     YGYFIVVIMQ FFILSYIIFK INYNLFNSKI LLLLSFILQQ SFLYYFTNNT AFHDTVLHYY
     PLSENTIIFG WIFYFFLGAY MGYNYERVLN FLERYLVIMI VLAVATYFVF IALANGDYWN
     VTSFSYSLTP YNSIMFIVIL GICTHFKTML FNTIQMISAF SFFIYLLHPI ILDSLFAYTN
     IFEDNTMVFL AISLLFILGL CIGVGMILRE FYIFRFIIGK QPYKLNINAY