ID   ICAC_STAAR              Reviewed;         350 AA.
AC   Q6GDD5;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Probable poly-beta-1,6-N-acetyl-D-glucosamine export protein;
DE            Short=PGA export protein;
DE            Short=Poly-beta-1,6-GlcNAc export protein;
DE   AltName: Full=Biofilm polysaccharide intercellular adhesin export protein;
DE            Short=Biofilm PIA export protein;
DE   AltName: Full=Intercellular adhesion protein C;
GN   Name=icaC; OrderedLocusNames=SAR2750;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Presumably involved in the export of the biofilm adhesin
CC       polysaccharide poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also
CC       referred to as PIA) across the cell membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the acyltransferase 3 family. {ECO:0000305}.
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DR   EMBL; BX571856; CAG41726.1; -; Genomic_DNA.
DR   RefSeq; WP_000723844.1; NC_002952.2.
DR   AlphaFoldDB; Q6GDD5; -.
DR   KEGG; sar:SAR2750; -.
DR   HOGENOM; CLU_064947_1_0_9; -.
DR   OMA; YHFYFVP; -.
DR   OrthoDB; 1979131at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   InterPro; IPR002656; Acyl_transf_3_dom.
DR   Pfam; PF01757; Acyl_transf_3; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..350
FT                   /note="Probable poly-beta-1,6-N-acetyl-D-glucosamine export
FT                   protein"
FT                   /id="PRO_0000208074"
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   350 AA;  41358 MW;  EDDB571FD3A0285E CRC64;
     MKKIRLELVY LRAIICAIII VTHLLTQITL KHENMEGGSL VLQFYIRNIV IFGTPCFIIL
     SQLLTTLNYQ KVTYRYLTTR VKYILIPYIL MGLFYSYSES LLTDTSFQKQ FIENVLLGQW
     YGYFIVVIMQ FFILSYIIFK INYNLFNSKI LLLLSFILQQ SFLYYFTNNT AFHDTVLHYY
     PLSENTIIFG WIFYFFLGAY MGYNYERVLN FLERYLVIMI VLAVATYFVF IALANGDYWN
     VTSFSYSLTP YNSIMFIVIL GICTHFKTML FNTIQMISAF SFFIYLLHPI ILDSLFAYTN
     IFEDNTMVFL AISLLFILGL CIGVGMILRE FYIFRFIIGK QPYKLNINAY