ID   ICAD_STAAM              Reviewed;         101 AA.
AC   Q7A2K4;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Poly-beta-1,6-N-acetyl-D-glucosamine synthesis protein IcaD;
DE            Short=PGA synthesis protein IcaD;
DE            Short=Poly-beta-1,6-GlcNAc synthesis protein IcaD;
DE   AltName: Full=Biofilm polysaccharide intercellular adhesin synthesis protein IcaD;
DE            Short=Biofilm PIA synthesis protein IcaD;
DE   AltName: Full=Intercellular adhesion protein D;
GN   Name=icaD; OrderedLocusNames=SAV2667;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Necessary for the synthesis of poly-beta-1,6-N-acetyl-D-
CC       glucosamine (PNAG, also referred to as PIA), a biofilm adhesin
CC       polysaccharide. Is required for full IcaA N-
CC       acetylglucosaminyltransferase activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IcaD family. {ECO:0000305}.
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DR   EMBL; BA000017; BAB58829.1; -; Genomic_DNA.
DR   RefSeq; WP_000240580.1; NC_002758.2.
DR   AlphaFoldDB; Q7A2K4; -.
DR   PaxDb; Q7A2K4; -.
DR   EnsemblBacteria; BAB58829; BAB58829; SAV2667.
DR   KEGG; sav:SAV2667; -.
DR   HOGENOM; CLU_2289916_0_0_9; -.
DR   OMA; SVITIRI; -.
DR   BioCyc; SAUR158878:SAV_RS14565-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR020510; IcaD.
DR   TIGRFAMs; TIGR03932; PIA_icaD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..101
FT                   /note="Poly-beta-1,6-N-acetyl-D-glucosamine synthesis
FT                   protein IcaD"
FT                   /id="PRO_0000084135"
FT   TRANSMEM        24..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   101 AA;  11783 MW;  3BE3E8E0CCF10F04 CRC64;
     MVKPRQREYP TLKSSLNIVR ETALIAISCV FWIYCLVVLL VYIGTIFEIH DESINTIRVA
     LNIENTEILD IFETMGIFAI IIFVFFTISI LIQKWQRGRE S