ICAD_STAAR
ID ICAD_STAAR Reviewed; 101 AA.
AC Q6GDD7;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Poly-beta-1,6-N-acetyl-D-glucosamine synthesis protein IcaD;
DE Short=PGA synthesis protein IcaD;
DE Short=Poly-beta-1,6-GlcNAc synthesis protein IcaD;
DE AltName: Full=Biofilm polysaccharide intercellular adhesin synthesis protein IcaD;
DE Short=Biofilm PIA synthesis protein IcaD;
DE AltName: Full=Intercellular adhesion protein D;
GN Name=icaD; OrderedLocusNames=SAR2748;
OS Staphylococcus aureus (strain MRSA252).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=282458;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSA252;
RX PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT for the rapid evolution of virulence and drug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC -!- FUNCTION: Necessary for the synthesis of poly-beta-1,6-N-acetyl-D-
CC glucosamine (PNAG, also referred to as PIA), a biofilm adhesin
CC polysaccharide. Is required for full IcaA N-
CC acetylglucosaminyltransferase activity (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IcaD family. {ECO:0000305}.
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DR EMBL; BX571856; CAG41724.1; -; Genomic_DNA.
DR RefSeq; WP_000240578.1; NC_002952.2.
DR AlphaFoldDB; Q6GDD7; -.
DR SMR; Q6GDD7; -.
DR KEGG; sar:SAR2748; -.
DR HOGENOM; CLU_2289916_0_0_9; -.
DR OMA; SVITIRI; -.
DR OrthoDB; 1909781at2; -.
DR Proteomes; UP000000596; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR020510; IcaD.
DR TIGRFAMs; TIGR03932; PIA_icaD; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT CHAIN 1..101
FT /note="Poly-beta-1,6-N-acetyl-D-glucosamine synthesis
FT protein IcaD"
FT /id="PRO_0000084137"
FT TRANSMEM 24..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..93
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 101 AA; 11769 MW; 94E3FE9A670775B8 CRC64;
MVKPRQREYP TLKSSLNIIR ETALIAISCV FWIYCLVVLL VYIGTIFEIH DESINTIRVA
LNIENTEILD IFETMGIFAI IIFVFFTISI LIQKWQKGRE S