ID   ICAD_STAAS              Reviewed;         101 AA.
AC   Q6G607;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Poly-beta-1,6-N-acetyl-D-glucosamine synthesis protein IcaD;
DE            Short=PGA synthesis protein IcaD;
DE            Short=Poly-beta-1,6-GlcNAc synthesis protein IcaD;
DE   AltName: Full=Biofilm polysaccharide intercellular adhesin synthesis protein IcaD;
DE            Short=Biofilm PIA synthesis protein IcaD;
DE   AltName: Full=Intercellular adhesion protein D;
GN   Name=icaD; OrderedLocusNames=SAS2553;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Necessary for the synthesis of poly-beta-1,6-N-acetyl-D-
CC       glucosamine (PNAG, also referred to as PIA), a biofilm adhesin
CC       polysaccharide. Is required for full IcaA N-
CC       acetylglucosaminyltransferase activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IcaD family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX571857; CAG44370.1; -; Genomic_DNA.
DR   RefSeq; WP_000240580.1; NC_002953.3.
DR   AlphaFoldDB; Q6G607; -.
DR   KEGG; sas:SAS2553; -.
DR   HOGENOM; CLU_2289916_0_0_9; -.
DR   OMA; SVITIRI; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR020510; IcaD.
DR   TIGRFAMs; TIGR03932; PIA_icaD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..101
FT                   /note="Poly-beta-1,6-N-acetyl-D-glucosamine synthesis
FT                   protein IcaD"
FT                   /id="PRO_0000084138"
FT   TRANSMEM        24..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   101 AA;  11783 MW;  3BE3E8E0CCF10F04 CRC64;
     MVKPRQREYP TLKSSLNIVR ETALIAISCV FWIYCLVVLL VYIGTIFEIH DESINTIRVA
     LNIENTEILD IFETMGIFAI IIFVFFTISI LIQKWQRGRE S