ID   ICAD_STAAW              Reviewed;         101 AA.
AC   Q79ZV3;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Poly-beta-1,6-N-acetyl-D-glucosamine synthesis protein IcaD;
DE            Short=PGA synthesis protein IcaD;
DE            Short=Poly-beta-1,6-GlcNAc synthesis protein IcaD;
DE   AltName: Full=Biofilm polysaccharide intercellular adhesin synthesis protein IcaD;
DE            Short=Biofilm PIA synthesis protein IcaD;
DE   AltName: Full=Intercellular adhesion protein D;
GN   Name=icaD; OrderedLocusNames=MW2587;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Necessary for the synthesis of poly-beta-1,6-N-acetyl-D-
CC       glucosamine (PNAG, also referred to as PIA), a biofilm adhesin
CC       polysaccharide. Is required for full IcaA N-
CC       acetylglucosaminyltransferase activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IcaD family. {ECO:0000305}.
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DR   EMBL; BA000033; BAB96452.1; -; Genomic_DNA.
DR   RefSeq; WP_000240580.1; NC_003923.1.
DR   AlphaFoldDB; Q79ZV3; -.
DR   EnsemblBacteria; BAB96452; BAB96452; BAB96452.
DR   KEGG; sam:MW2587; -.
DR   HOGENOM; CLU_2289916_0_0_9; -.
DR   OMA; SVITIRI; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR020510; IcaD.
DR   TIGRFAMs; TIGR03932; PIA_icaD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..101
FT                   /note="Poly-beta-1,6-N-acetyl-D-glucosamine synthesis
FT                   protein IcaD"
FT                   /id="PRO_0000084140"
FT   TRANSMEM        24..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   101 AA;  11783 MW;  3BE3E8E0CCF10F04 CRC64;
     MVKPRQREYP TLKSSLNIVR ETALIAISCV FWIYCLVVLL VYIGTIFEIH DESINTIRVA
     LNIENTEILD IFETMGIFAI IIFVFFTISI LIQKWQRGRE S