ID   ICAD_STAEP              Reviewed;         101 AA.
AC   P69519; O54214;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Poly-beta-1,6-N-acetyl-D-glucosamine synthesis protein IcaD;
DE            Short=PGA synthesis protein IcaD;
DE            Short=Poly-beta-1,6-GlcNAc synthesis protein IcaD;
DE   AltName: Full=Biofilm polysaccharide intercellular adhesin synthesis protein IcaD;
DE            Short=Biofilm PIA synthesis protein IcaD;
DE   AltName: Full=Intercellular adhesion protein D;
GN   Name=icaD;
OS   Staphylococcus epidermidis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1282;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=97-337;
RA   Li H., Wen Y.;
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SE5;
RX   PubMed=15096544; DOI=10.1099/jmm.0.05372-0;
RA   Handke L.D., Conlon K.M., Slater S.R., Elbaruni S., Fitzpatrick F.,
RA   Humphreys H., Giles W.P., Rupp M.E., Fey P.D., O'Gara J.P.;
RT   "Genetic and phenotypic analysis of biofilm phenotypic variation in
RT   multiple Staphylococcus epidermidis isolates.";
RL   J. Med. Microbiol. 53:367-374(2004).
CC   -!- FUNCTION: Necessary for the synthesis of poly-beta-1,6-N-acetyl-D-
CC       glucosamine (PNAG, also referred to as PIA), a biofilm adhesin
CC       polysaccharide. Is required for full IcaA N-
CC       acetylglucosaminyltransferase activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IcaD family. {ECO:0000305}.
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DR   EMBL; AY382582; AAQ88121.1; -; Genomic_DNA.
DR   EMBL; AY138959; AAN17772.1; -; Genomic_DNA.
DR   RefSeq; WP_002477257.1; NZ_WLUZ01000001.1.
DR   AlphaFoldDB; P69519; -.
DR   SMR; P69519; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR020510; IcaD.
DR   TIGRFAMs; TIGR03932; PIA_icaD; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..101
FT                   /note="Poly-beta-1,6-N-acetyl-D-glucosamine synthesis
FT                   protein IcaD"
FT                   /id="PRO_0000084141"
FT   TRANSMEM        21..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   101 AA;  11951 MW;  CBAD3678D375B03B CRC64;
     MVKPRQRQYP TVTSYLNIVR ESLFITISGV FWMYCIVVMI VYIGTLINSQ MESVITIRIA
     LNVENTEIYK LFGWMSLFVL IIFIFFTFSL AFQKYKKGRD I