ID   ICAR_STAAW              Reviewed;         186 AA.
AC   Q79ZV4;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Biofilm operon icaADBC HTH-type negative transcriptional regulator IcaR;
DE   AltName: Full=Intercellular adhesion protein R;
GN   Name=icaR; OrderedLocusNames=MW2585;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Represses transcription of the icaADBC operon necessary for
CC       biofilm production. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Binding to the ica operator DNA involves two IcaR dimers
CC       and is highly cooperative. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000033; BAB96450.1; -; Genomic_DNA.
DR   RefSeq; WP_000653261.1; NC_003923.1.
DR   AlphaFoldDB; Q79ZV4; -.
DR   SMR; Q79ZV4; -.
DR   EnsemblBacteria; BAB96450; BAB96450; BAB96450.
DR   KEGG; sam:MW2585; -.
DR   HOGENOM; CLU_124987_0_0_9; -.
DR   OMA; ETNSYFA; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR041646; IcaR_C.
DR   Pfam; PF18665; TetR_C_37; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..186
FT                   /note="Biofilm operon icaADBC HTH-type negative
FT                   transcriptional regulator IcaR"
FT                   /id="PRO_0000070602"
FT   DOMAIN          1..59
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        22..41
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   186 AA;  21987 MW;  F1C76B0056C7ECAB CRC64;
     MKDKIIDNAI TLFSEKGYDG TTLDDIAKSV NIKKASLYYH FDSKKSIYEQ SVKCCFDYLN
     NIIMMNQNKS NYSIDALYQF LFEFIFDIEE RYIRMYVQLS NTPEEFSGNI YGQIQDLNQS
     LSKEIAKFYD ESKIKMTKED FQNLILLFLE SWYLKASFSQ KFGAVEESKS QFKDEVYSLL
     NIFLKK