ID   ICAR_STAEP              Reviewed;         185 AA.
AC   Q8GLC6;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Biofilm operon icaADBC HTH-type negative transcriptional regulator IcaR;
DE   AltName: Full=Intercellular adhesion protein R;
GN   Name=icaR;
OS   Staphylococcus epidermidis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1282;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=97-337;
RA   Li H., Wen Y.;
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SE5;
RX   PubMed=15096544; DOI=10.1099/jmm.0.05372-0;
RA   Handke L.D., Conlon K.M., Slater S.R., Elbaruni S., Fitzpatrick F.,
RA   Humphreys H., Giles W.P., Rupp M.E., Fey P.D., O'Gara J.P.;
RT   "Genetic and phenotypic analysis of biofilm phenotypic variation in
RT   multiple Staphylococcus epidermidis isolates.";
RL   J. Med. Microbiol. 53:367-374(2004).
CC   -!- FUNCTION: Represses transcription of the icaADBC operon necessary for
CC       biofilm production. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Binding to the ica operator DNA involves two IcaR dimers
CC       and is highly cooperative. {ECO:0000250}.
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DR   EMBL; AY382582; AAQ88119.1; -; Genomic_DNA.
DR   EMBL; AY138959; AAN17770.1; -; Genomic_DNA.
DR   RefSeq; WP_002484503.1; NZ_WJUN01000004.1.
DR   AlphaFoldDB; Q8GLC6; -.
DR   SMR; Q8GLC6; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR041646; IcaR_C.
DR   Pfam; PF18665; TetR_C_37; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..185
FT                   /note="Biofilm operon icaADBC HTH-type negative
FT                   transcriptional regulator IcaR"
FT                   /id="PRO_0000070603"
FT   DOMAIN          1..59
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        22..41
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   185 AA;  22154 MW;  63007122D3A5824D CRC64;
     MKDKIIDNAI TLFSEKGYDG TTLDDISKSV NIKKASLYYH YDNKEEIYRK SVENCFNYFI
     DFLLRNHDDN YSIDGLYQFL FKFIFDVDER YIKLYVQLSS APEALNSEIK HHLQEINTTL
     HDELIKYYDP THIALNKEDF INLILLFLET WYFRASFSQK FGVIEDSKNR FKDQVYSLLN
     VFLKK