ID   ICE2_ASCSU              Reviewed;          65 AA.
AC   P07852;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Chymotrypsin/elastase isoinhibitors 2 to 5;
OS   Ascaris suum (Pig roundworm) (Ascaris lumbricoides).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Ascaridomorpha; Ascaridoidea; Ascarididae; Ascaris.
OX   NCBI_TaxID=6253;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6564898; DOI=10.1016/0003-9861(84)90530-7;
RA   Babin D.R., Peanasky R.J., Goos S.M.;
RT   "The isoinhibitors of chymotrypsin/elastase from Ascaris lumbricoides: the
RT   primary structure.";
RL   Arch. Biochem. Biophys. 232:143-161(1984).
CC   -!- FUNCTION: Defends the organism against the host's proteinases.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the serine protease inhibitor-like (TIL domain-
CC       containing) family. {ECO:0000305}.
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DR   AlphaFoldDB; P07852; -.
DR   SMR; P07852; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   Pfam; PF01826; TIL; 1.
DR   SUPFAM; SSF57567; SSF57567; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor; Secreted;
KW   Serine protease inhibitor.
FT   CHAIN           1..65
FT                   /note="Chymotrypsin/elastase isoinhibitors 2 to 5"
FT                   /id="PRO_0000174330"
FT   DOMAIN          4..59
FT                   /note="TIL"
FT   SITE            30..31
FT                   /note="Reactive bond"
FT   DISULFID        4..37
FT                   /evidence="ECO:0000250"
FT   DISULFID        13..32
FT                   /evidence="ECO:0000250"
FT   DISULFID        16..28
FT                   /evidence="ECO:0000250"
FT   DISULFID        20..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..53
FT                   /evidence="ECO:0000250"
FT   VARIANT         25
FT                   /note="K -> N (in inhibitor 2 and inhibitor 4)"
FT   VARIANT         40
FT                   /note="T -> S (in inhibitor 2 and inhibitor 4)"
FT   VARIANT         64..65
FT                   /note="Missing (in inhibitor 2)"
FT   VARIANT         65
FT                   /note="K -> E (in inhibitor 3)"
FT   VARIANT         65
FT                   /note="K -> R"
SQ   SEQUENCE   65 AA;  7242 MW;  B4E51CA166EA4BE3 CRC64;
     RKPCGKNEVW TECTGCELKC GQDEKTPCAL MCRPPSCECT PGRGMRRTHD GKCVPVSECP
     RKMPK