ICE2_DROME
ID ICE2_DROME Reviewed; 684 AA.
AC Q8SZZ8; Q9VDE0;
DT 01-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Little elongation complex subunit 2;
DE AltName: Full=Interactor of little elongator complex ELL subunit 2;
GN Name=Ice2; ORFNames=CG10825;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION, AND IDENTIFICATION IN THE LEC COMPLEX.
RX PubMed=22195968; DOI=10.1016/j.molcel.2011.12.008;
RA Smith E.R., Lin C., Garrett A.S., Thornton J., Mohaghegh N., Hu D.,
RA Jackson J., Saraf A., Swanson S.K., Seidel C., Florens L., Washburn M.P.,
RA Eissenberg J.C., Shilatifard A.;
RT "The little elongation complex regulates small nuclear RNA transcription.";
RL Mol. Cell 44:954-965(2011).
CC -!- FUNCTION: Component of the little elongation complex (LEC), a complex
CC required to regulate small nuclear RNA (snRNA) gene transcription by
CC RNA polymerase II and III. {ECO:0000269|PubMed:22195968}.
CC -!- SUBUNIT: Component of the little elongation complex (LEC), at least
CC composed of Ell, Eaf, Ice1 and Ice2. {ECO:0000269|PubMed:22195968}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ICE2 family. {ECO:0000305}.
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DR EMBL; AE014297; AAF55856.2; -; Genomic_DNA.
DR EMBL; AY069681; AAL39826.1; -; mRNA.
DR RefSeq; NP_650946.3; NM_142689.4.
DR AlphaFoldDB; Q8SZZ8; -.
DR SMR; Q8SZZ8; -.
DR BioGRID; 67478; 5.
DR IntAct; Q8SZZ8; 3.
DR STRING; 7227.FBpp0083418; -.
DR PaxDb; Q8SZZ8; -.
DR DNASU; 42507; -.
DR EnsemblMetazoa; FBtr0084015; FBpp0083418; FBgn0038860.
DR GeneID; 42507; -.
DR KEGG; dme:Dmel_CG10825; -.
DR UCSC; CG10825-RA; d. melanogaster.
DR CTD; 79664; -.
DR FlyBase; FBgn0038860; Ice2.
DR VEuPathDB; VectorBase:FBgn0038860; -.
DR eggNOG; ENOG502QUWA; Eukaryota.
DR HOGENOM; CLU_416366_0_0_1; -.
DR InParanoid; Q8SZZ8; -.
DR OMA; CGCEIMT; -.
DR OrthoDB; 518363at2759; -.
DR PhylomeDB; Q8SZZ8; -.
DR SignaLink; Q8SZZ8; -.
DR BioGRID-ORCS; 42507; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 42507; -.
DR PRO; PR:Q8SZZ8; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038860; Expressed in cleaving embryo and 22 other tissues.
DR ExpressionAtlas; Q8SZZ8; baseline and differential.
DR Genevisible; Q8SZZ8; DM.
DR GO; GO:0032783; C:super elongation complex; IPI:FlyBase.
DR GO; GO:0008023; C:transcription elongation factor complex; IDA:UniProtKB.
DR InterPro; IPR019535; ICE2_C.
DR Pfam; PF10505; NARG2_C; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..684
FT /note="Little elongation complex subunit 2"
FT /id="PRO_0000430425"
FT REGION 69..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 78896 MW; F7FE756B8D167A2F CRC64;
MFSMDSFAMD KDAKLYEGNA LFRNQPSYKV FNKSFEHVDD ALYTLLNEVE PDVLRMELQE
TGDLFKSFNR NSALRDPRNN EVPPKPTRDL TTASSLYSFP NPLEQYSELN LKQQAACMRV
LLAWQCSQPV DEQDIVVWQA TEKKRYNEQQ RVQKYIHDHE QGRKEVIYAP MKSLVAVYRK
WYELGVKKLQ QTYPNDSYMT FSGLPQLPQC RSLNAQTASI EQVELERIVG RVRLLPEVEV
RHEALRTLRL RLDRYATRET RAPVQLLREE DKELELEAGN VFVLPLDSLL MLLTTGSYID
LPTEMFLSLR ESPNSKHKCM EFQSPFPPRN CGWHTNSLIL KLAYGAYISQ PGQAKWLDFN
INGAVKEVPD EPACDKSSID LQMVYKPRAI DQQPSDIEDG NCNSALVSWT LRCKGEGDDC
NDFQIFSTLS IPAVKDSSGK EPLGCHFIKL ENKPDCGCEI MSKYELISAW VQLKLMRAEM
GHCTRISLRD FEPMLEEKLT LISLEQQLHD YYNTSMPQLL SNLCEFLKLL DTVPAGDYLL
RYSPKYKDKF LLCIVTKEAT PQSFQLHQLL TESIPSDQAF LTQSSYLPIS PTLCGRLHEE
LHLLPCAFPA KANGRSVQRR KVVVPIPEPS RQAPVRRQRL KKWSEAQTRE FRRRCKVDQK
KRARARKTAA ANKEKIELEK IMTL
