ICE2_YEAST
ID ICE2_YEAST Reviewed; 491 AA.
AC P40499; D6VVJ7; Q6B2T7;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Protein ICE2;
DE AltName: Full=Inheritance of cortical ER protein 2;
GN Name=ICE2; OrderedLocusNames=YIL090W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169870;
RA Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL Nature 387:84-87(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 606 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; Z46728; CAA86704.1; -; Genomic_DNA.
DR EMBL; AY692643; AAT92662.1; -; Genomic_DNA.
DR EMBL; BK006942; DAA08463.1; -; Genomic_DNA.
DR PIR; S49790; S49790.
DR RefSeq; NP_012176.1; NM_001179438.1.
DR AlphaFoldDB; P40499; -.
DR BioGRID; 34902; 677.
DR IntAct; P40499; 45.
DR STRING; 4932.YIL090W; -.
DR TCDB; 8.A.169.1.1; the fungal inheritance of cortical er protein 2 (ice2) family.
DR MaxQB; P40499; -.
DR PaxDb; P40499; -.
DR PRIDE; P40499; -.
DR EnsemblFungi; YIL090W_mRNA; YIL090W; YIL090W.
DR GeneID; 854718; -.
DR KEGG; sce:YIL090W; -.
DR SGD; S000001352; ICE2.
DR VEuPathDB; FungiDB:YIL090W; -.
DR eggNOG; ENOG502QRTT; Eukaryota.
DR HOGENOM; CLU_027878_2_0_1; -.
DR InParanoid; P40499; -.
DR OMA; DVGGRTC; -.
DR BioCyc; YEAST:G3O-31350-MON; -.
DR PRO; PR:P40499; -.
DR Proteomes; UP000002311; Chromosome IX.
DR RNAct; P40499; protein.
DR GO; GO:0032541; C:cortical endoplasmic reticulum; IDA:SGD.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IDA:SGD.
DR GO; GO:0097038; C:perinuclear endoplasmic reticulum; IDA:SGD.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IMP:SGD.
DR GO; GO:0048309; P:endoplasmic reticulum inheritance; IMP:SGD.
DR GO; GO:0031204; P:post-translational protein targeting to membrane, translocation; IMP:SGD.
DR GO; GO:0036228; P:protein localization to nuclear inner membrane; IMP:SGD.
DR GO; GO:0000921; P:septin ring assembly; IMP:SGD.
DR InterPro; IPR013635; Ice2.
DR PANTHER; PTHR31726; PTHR31726; 1.
DR Pfam; PF08426; ICE2; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..491
FT /note="Protein ICE2"
FT /id="PRO_0000202975"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..40
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..149
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..184
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..218
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 240..294
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..373
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 395..413
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 435..461
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 483..491
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 93
FT /note="S -> P (in Ref. 3; AAT92662)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 491 AA; 56333 MW; BAEC655534E04239 CRC64;
MTSLSKSFMQ SGRICAACFY LLFTLLSIPI SFKVGGLECG LSFTVTLFTL YFITTTLNVL
ARRHGGRLYI FFTNCLYYSQ HFIIASLLYL FLSGFSNDEL GNVLKNKYNE SESFLEALKN
SLNSNQINYV LYYYYYRFVV QPWQFVLTKS TPFFTLSEGF FTILAIQAVG ETNRWLSNDL
NSNTWIISSL LTSGGVITAS LYYLYRIYVT PIWPLSIQTA SLLGLVLSMV CGLGLYGIVS
QKGSVIESSL FFAYIVRCIY EISPKLATTA TDEILNLFKD VWQKHQRNLP TADNLLCYFH
NVILKNAEVL WGSFIPRGRK KTGDFHDKLI SILSFEKVSL ISKPFWKFFK NFTFSVPLSI
NEFCQVTIKM ASESVSPAIV INLCFRVLMF YSATRIIPAL QRKNDKQLRK SRRIMKGLYW
YSPCILIAMY THLILQYSGE LKKDLCIWGC SEKWFGVDQP EIIVDSWGFW NWCNIFCTIL
VYATELIGSG S
