ID   ICEF1_RAT               Reviewed;         406 AA.
AC   Q80VL0;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Interactor protein for cytohesin exchange factors 1;
GN   Name=Ipcef1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PSCD1; PSCD2; PSCD3 AND PSCD4,
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RX   PubMed=12920129; DOI=10.1074/jbc.m304078200;
RA   Venkateswarlu K.;
RT   "Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds
RT   cytohesin 2 and modifies its activity.";
RL   J. Biol. Chem. 278:43460-43469(2003).
RN   [2]
RP   INTERACTION WITH PSCD2.
RX   PubMed=16413275; DOI=10.1016/s0076-6879(05)04024-3;
RA   Venkateswarlu K.;
RT   "Analysis of the interaction between cytohesin 2 and IPCEF1.";
RL   Methods Enzymol. 404:252-266(2005).
CC   -!- FUNCTION: Enhances the promotion of guanine-nucleotide exchange by
CC       PSCD2 on ARF6 in a concentration-dependent manner.
CC   -!- SUBUNIT: Interacts with guanine-nucleotide exchange factors PSCD1,
CC       PSCD2, PSCD3 and PSCD4. {ECO:0000269|PubMed:12920129,
CC       ECO:0000269|PubMed:16413275}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12920129}. Cell
CC       membrane {ECO:0000269|PubMed:12920129}. Note=Translocated with PSCD2 to
CC       the plasma membrane upon epidermal growth factor (EGF) stimulation.
CC   -!- TISSUE SPECIFICITY: Expressed in brain, spleen, lung, testis and
CC       kidney. {ECO:0000269|PubMed:12920129}.
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DR   EMBL; AJ536192; CAD60208.1; -; mRNA.
DR   RefSeq; NP_001164270.1; NM_001170799.1.
DR   AlphaFoldDB; Q80VL0; -.
DR   SMR; Q80VL0; -.
DR   BioGRID; 262707; 1.
DR   STRING; 10116.ENSRNOP00000024461; -.
DR   PaxDb; Q80VL0; -.
DR   PRIDE; Q80VL0; -.
DR   GeneID; 361474; -.
DR   KEGG; rno:361474; -.
DR   UCSC; RGD:735159; rat.
DR   CTD; 26034; -.
DR   RGD; 735159; Ipcef1.
DR   VEuPathDB; HostDB:ENSRNOG00000018163; -.
DR   eggNOG; KOG1738; Eukaryota.
DR   HOGENOM; CLU_051850_0_0_1; -.
DR   InParanoid; Q80VL0; -.
DR   OMA; VIHHEST; -.
DR   OrthoDB; 1121556at2759; -.
DR   PhylomeDB; Q80VL0; -.
DR   PRO; PR:Q80VL0; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000018163; Expressed in frontal cortex and 12 other tissues.
DR   GO; GO:0005829; C:cytosol; IDA:RGD.
DR   GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR   GO; GO:0019904; F:protein domain specific binding; IPI:RGD.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..406
FT                   /note="Interactor protein for cytohesin exchange factors 1"
FT                   /id="PRO_0000326632"
FT   DOMAIN          13..112
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          118..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          228..285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..406
FT                   /note="Necessary for interaction with PSCD2 and to
FT                   translocate to the plasma membrane"
FT   REGION          383..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..173
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..264
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..285
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   406 AA;  45686 MW;  78F84BEC1A36BDB4 CRC64;
     MSRRRISCKD LGHADCQGWL YKKKEKGTFL SNKWKKFWVV LKGSSLYWYG NQLAEKADGF
     VNLPDFTVER ASECKKKNAF KINHPQIKTF YFAAENLQEM NMWLNKLGFA VTHKESTTKD
     EECYSESEQE DPETAVEAPP PPSASATSSP VAARRASSSS PKRRETSCSF SSLENTVKAP
     SRFSSSGSKE RQSWLDIVNS SPATEDVGHP LSFAVQVHTL ASSEASSCRV SENSSTTPES
     GCLNSLSSDD TSSLNNSQDH LTVPDRASGS RMTDRDEIKS SEDDEMEKLY KSLEQASLSP
     LGDRRPSTKK ELRKSFVKRC KNPSINEKLH KIRTLNSTLK CKEHDLAMIN QLLDDPKLTA
     RKYREWKVMN TLLIQDIYQQ QVPQDPEVTP QEIMNPTSSD CVENSL