ID   ICFG_SYNY3              Reviewed;         634 AA.
AC   P37979; P73610;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Protein IcfG;
GN   Name=icfG; OrderedLocusNames=slr1860;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8075401; DOI=10.1007/bf00028880;
RA   Beuf L., Bedu S., Durand M.C., Joset F.;
RT   "A protein involved in co-ordinated regulation of inorganic carbon and
RT   glucose metabolism in the facultative photoautotrophic cyanobacterium
RT   Synechocystis PCC6803.";
RL   Plant Mol. Biol. 25:855-864(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Involved in cross-regulation of inorganic carbon and glucose
CC       metabolisms.
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DR   EMBL; X75568; CAA53246.1; -; Genomic_DNA.
DR   EMBL; BA000022; BAA17654.1; -; Genomic_DNA.
DR   PIR; S77096; S77096.
DR   AlphaFoldDB; P37979; -.
DR   SMR; P37979; -.
DR   IntAct; P37979; 1.
DR   STRING; 1148.1652735; -.
DR   PaxDb; P37979; -.
DR   EnsemblBacteria; BAA17654; BAA17654; BAA17654.
DR   KEGG; syn:slr1860; -.
DR   eggNOG; COG2208; Bacteria.
DR   eggNOG; COG2770; Bacteria.
DR   OMA; IGDVCDK; -.
DR   PhylomeDB; P37979; -.
DR   BRENDA; 3.1.3.16; 6192.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0006935; P:chemotaxis; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.60.40.10; -; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR036457; PPM-type_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase_dom.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF81606; SSF81606; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS51746; PPM_2; 1.
PE   4: Predicted;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..634
FT                   /note="Protein IcfG"
FT                   /id="PRO_0000057792"
FT   DOMAIN          306..361
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          385..633
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01082"
FT   CONFLICT        317..331
FT                   /note="KASQAIAAGDLDYEI -> EGFPSDRRGRFRLLKL (in Ref. 1;
FT                   CAA53246)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        359..364
FT                   /note="LIAQEV -> HDSSGS (in Ref. 1; CAA53246)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        375..377
FT                   /note="KGR -> QGRRVQ (in Ref. 1; CAA53246)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        423..424
FT                   /note="IV -> MS (in Ref. 1; CAA53246)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   634 AA;  70962 MW;  BA9D70CE53E6CD0C CRC64;
     MKMKLIQPFI QSIRFRIVGL LLLCLIPPTL GGIFLIDSYT GRQLKKIAEQ DLQSRARLII
     QLISRSDRER QQSTAFVASQ PAIVEFNVEA SQYFLNEFIK FHQWNGFFVV ANQEGELVAG
     SDGANQEKGL PLKHWFEEVK DKNRHLNRLF PGKTYAESKD CLIVPIHSKN DQTQIGIVVE
     CIPLPVIADF VQKILKDAEL ERILLVNYEG YIYADTDFKN YGVLENKKKS PLVNRLLNDQ
     SGFVYSQGKF SYLSPVHLRG AKTWGLIVEN SESDIQAAIL NVNRIGYLLV LVIGGIVAYA
     SWMVIHHSTV PILDLTKASQ AIAAGDLDYE ININQGNRQD EIGILGNSFI YMKNQIKTLI
     AQEVKDGVNR LELEKGRQIQ QNFLPISLPD LQQWQINAVF EPARSVSGDF YDAFLLGDDY
     LAIVIGDVCD KGVGAAMFMG LFRSLLRVFS GETMPGDTCI RDVNYKCSAN DGNGKKKVIV
     QFLNAVRLTN DYIATEHGDM AMFATLFFGV IDISNGNLSY INAGHEPVFI LNSEGIKHRL
     KSTGPAVGMM PNSTFTIDSL KIDPGEMLIG YTDGVTDARS PTKEFFGRQR LMETLTANFS
     AKTEILDIIK QELIGHIDGS IQFDDITMIA VYRN