ID   ICHY_CAIMO              Reviewed;          65 AA.
AC   P83039;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Chymotrypsin inhibitor;
DE   AltName: Full=DPCI;
OS   Cairina moschata (Muscovy duck).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Cairina.
OX   NCBI_TaxID=8855 {ECO:0000305};
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBUNIT, AND MASS SPECTROMETRY.
RC   TISSUE=Pancreas;
RX   PubMed=11959032; DOI=10.1016/s1096-4959(02)00008-8;
RA   Wilimowska-Pelc A., Olichwier Z., Mazurkiewicz A., Kowalska J., Wilusz T.;
RT   "Kazal-type chymotrypsin inhibitor from duck pancreas.";
RL   Comp. Biochem. Physiol. 131B:499-507(2002).
CC   -!- FUNCTION: Inhibits chymotrypsin. {ECO:0000269|PubMed:11959032,
CC       ECO:0000305}.
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:11959032}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=7190.9; Mass_error=2; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:11959032};
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DR   AlphaFoldDB; P83039; -.
DR   SMR; P83039; -.
DR   MEROPS; I01.970; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR039932; Spink4-like.
DR   PANTHER; PTHR21179; PTHR21179; 1.
DR   Pfam; PF00050; Kazal_1; 1.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF100895; SSF100895; 1.
DR   PROSITE; PS00282; KAZAL_1; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor; Secreted;
KW   Serine protease inhibitor.
FT   CHAIN           1..65
FT                   /note="Chymotrypsin inhibitor"
FT                   /id="PRO_0000073031"
FT   DOMAIN          7..64
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   SITE            24..25
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        13..44
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        22..41
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DISULFID        30..62
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
SQ   SEQUENCE   65 AA;  7195 MW;  360AA7F1AA515D47 CRC64;
     ELDEGNGLRR PVCGEMAELL ACPLVNLPVC GTDGNTYANE CLLCVQKMKT RQDIRILNNG
     RCRDT