ID   ICIA_SOLTU              Reviewed;          71 AA.
AC   P01052;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Chymotrypsin inhibitor I, A, B and C subunits;
OS   Solanum tuberosum (Potato).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4113;
RN   [1]
RP   PROTEIN SEQUENCE (SUBUNIT A).
RC   STRAIN=cv. Ulster Prince;
RX   PubMed=4595280; DOI=10.1042/bj1370101;
RA   Richardson M.;
RT   "Chymotryptic inhibitor I from potatoes. The amino acid sequence of subunit
RT   A.";
RL   Biochem. J. 137:101-112(1974).
RN   [2]
RP   PROTEIN SEQUENCE (SUBUNITS B AND C).
RC   STRAIN=cv. Ulster Prince;
RX   PubMed=4606338; DOI=10.1016/0014-5793(74)80798-2;
RA   Richardson M., Cossins L.;
RT   "Chymotryptic inhibitor I from potatoes: the amino acid sequences of
RT   subunits B, C, and D.";
RL   FEBS Lett. 45:11-13(1974).
RN   [3]
RP   ERRATUM OF PUBMED:4606338, AND SEQUENCE REVISION.
RA   Richardson M., Cossins L.;
RL   FEBS Lett. 52:161-161(1975).
CC   -!- FUNCTION: Inhibits both chymotrypsin and trypsin.
CC   -!- SUBUNIT: Heterogeneous tetramers of similar chains.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I13 (potato type I serine
CC       protease inhibitor) family. {ECO:0000305}.
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DR   PIR; A01291; TIPO1A.
DR   PIR; S07233; S07233.
DR   AlphaFoldDB; P01052; -.
DR   SMR; P01052; -.
DR   MEROPS; I13.006; -.
DR   PRIDE; P01052; -.
DR   Proteomes; UP000011115; Unassembled WGS sequence.
DR   ExpressionAtlas; P01052; baseline and differential.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0009611; P:response to wounding; IEA:InterPro.
DR   InterPro; IPR000864; Prot_inh_pot1.
DR   InterPro; IPR036354; Prot_inh_pot1_sf.
DR   PANTHER; PTHR33091; PTHR33091; 1.
DR   Pfam; PF00280; potato_inhibit; 1.
DR   PRINTS; PR00292; POTATOINHBTR.
DR   SUPFAM; SSF54654; SSF54654; 1.
DR   PROSITE; PS00285; POTATO_INHIBITOR; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Protease inhibitor; Reference proteome;
KW   Serine protease inhibitor.
FT   CHAIN           1..71
FT                   /note="Chymotrypsin inhibitor I, A, B and C subunits"
FT                   /id="PRO_0000217653"
FT   SITE            47..48
FT                   /note="Reactive bond"
FT   VARIANT         6
FT                   /note="D -> K (in components B and C)"
FT   VARIANT         10
FT                   /note="Q -> S"
FT   VARIANT         24
FT                   /note="E -> G (in components B and C)"
FT   VARIANT         34
FT                   /note="S -> T"
FT   VARIANT         37
FT                   /note="H -> Q (in component C)"
FT   VARIANT         47
FT                   /note="M -> L"
FT   VARIANT         49
FT                   /note="F -> Y (in components B and C)"
FT   VARIANT         59
FT                   /note="D -> N (in components B and C)"
FT   VARIANT         63
FT                   /note="S -> N (in components B and C)"
FT   VARIANT         63
FT                   /note="S -> Y (in components B and C)"
SQ   SEQUENCE   71 AA;  8033 MW;  83323AE6631D223F CRC64;
     KEFECDGKLQ WPELIGVPTK LAKEIIEKQN SLISNVHILL NGSPVTMDFR CNRVRLFDDI
     LGSVVQIPRV A