ID   ICIC_HORVU              Reviewed;          77 AA.
AC   P01054;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   11-DEC-2019, entry version 72.
DE   RecName: Full=Subtilisin-chymotrypsin inhibitor CI-1C;
OS   Hordeum vulgare (Barley).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum.
OX   NCBI_TaxID=4513;
RN   [1]
RP   PROTEIN SEQUENCE.
RA   Svendsen I., Boisen S., Hejgaard J.;
RT   "Amino acid sequence of serine protease inhibitor CI-1 from barley.
RT   Homology with barley inhibitor CI-2, potato inhibitor I, and leech eglin.";
RL   Carlsberg Res. Commun. 47:45-53(1982).
RN   [2]
RP   REACTIVE SITE.
RA   Jonassen I., Svendsen I.;
RT   "Identification of the reactive sites in two homologous serine proteinase
RT   inhibitors isolated from barley.";
RL   Carlsberg Res. Commun. 47:199-203(1982).
CC   -!- FUNCTION: Inhibits both subtilisin and chymotrypsin.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I13 (potato type I serine
CC       protease inhibitor) family. {ECO:0000305}.
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DR   PIR; A01293; EIBH1C.
DR   MEROPS; I13.005; -.
DR   ExpressionAtlas; P01054; differential.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0009611; P:response to wounding; IEA:InterPro.
DR   InterPro; IPR000864; Prot_inh_pot1.
DR   InterPro; IPR036354; Prot_inh_pot1_sf.
DR   PANTHER; PTHR33091; PTHR33091; 1.
DR   Pfam; PF00280; potato_inhibit; 1.
DR   PRINTS; PR00292; POTATOINHBTR.
DR   SUPFAM; SSF54654; SSF54654; 1.
DR   PROSITE; PS00285; POTATO_INHIBITOR; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Protease inhibitor; Serine protease inhibitor.
FT   CHAIN           1..77
FT                   /note="Subtilisin-chymotrypsin inhibitor CI-1C"
FT                   /id="PRO_0000217646"
FT   SITE            24..25
FT                   /note="Reactive bond for subtilisin"
FT   SITE            53..54
FT                   /note="Reactive bond for chymotrypsin and subtilisin"
SQ   SEQUENCE   77 AA;  8258 MW;  02D2F35F0C5FDC85 CRC64;
     YPEPTEGSIG ASGAKTSWPE VVGMSAEKAK EIILRDKPNA QIEVIPVDAM VPLNFNPNRV
     FVLVHKATTV AZVSRVG