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APBP2_MOUSE
ID   APBP2_MOUSE             Reviewed;         585 AA.
AC   Q9DAX9; Q5SX12; Q80U61;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Amyloid protein-binding protein 2 {ECO:0000305};
DE   AltName: Full=Amyloid beta precursor protein-binding protein 2 {ECO:0000250|UniProtKB:Q92624};
DE            Short=APP-BP2 {ECO:0000250|UniProtKB:Q92624};
GN   Name=Appbp2 {ECO:0000312|MGI:MGI:1914134};
GN   Synonyms=Kiaa0228 {ECO:0000303|PubMed:12693553};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Placenta;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 29-585.
RC   TISSUE=Brain;
RX   PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA   Nakajima D., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT   The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 10:35-48(2003).
CC   -!- FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3
CC       ubiquitin-protein ligase complex of the DesCEND (destruction via C-end
CC       degrons) pathway, which recognizes a C-degron located at the extreme C
CC       terminus of target proteins, leading to their ubiquitination and
CC       degradation. The C-degron recognized by the DesCEND pathway is usually
CC       a motif of less than ten residues and can be present in full-length
CC       proteins, truncated proteins or proteolytically cleaved forms. The
CC       CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-
CC       Xaa-Gly degron at the C-terminus, leading to their ubiquitination and
CC       degradation. The CRL2(APPBP2) complex mediates ubiquitination and
CC       degradation of truncated SELENOV selenoproteins produced by failed
CC       UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron. May play a
CC       role in intracellular protein transport: may be involved in the
CC       translocation of APP along microtubules toward the cell surface.
CC       {ECO:0000250|UniProtKB:Q92624}.
CC   -!- ACTIVITY REGULATION: E3 ubiquitin-protein ligase activity of the
CC       CRL2(APPBP2) complex is inhibited by APP.
CC       {ECO:0000250|UniProtKB:Q92624}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000250|UniProtKB:Q92624}.
CC   -!- SUBUNIT: Component of a CRL2 E3 ubiquitin-protein ligase complex, also
CC       named ECS (Elongin BC-CUL2/5-SOCS-box protein) complex, composed of
CC       CUL2, Elongin BC (ELOB and ELOC), RBX1 and substrate-specific adapter
CC       APPBP2. Interacts with APP; APP interaction inhibits the E3 ubiquitin-
CC       protein ligase activity of the CRL2(APPBP2) complex.
CC       {ECO:0000250|UniProtKB:Q92624}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92624}.
CC       Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q92624}. Membrane
CC       {ECO:0000250|UniProtKB:Q92624}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q92624}. Note=Associated with membranes and
CC       microtubules. {ECO:0000250|UniProtKB:Q92624}.
CC   -!- PTM: Rapidly degraded by the proteasome upon overexpression of a C-
CC       terminal fragment of APP. {ECO:0000250|UniProtKB:Q92624}.
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DR   EMBL; AK005440; BAB24034.1; -; mRNA.
DR   EMBL; AL596183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC018442; AAH18442.1; -; mRNA.
DR   EMBL; BC019152; AAH19152.1; -; mRNA.
DR   EMBL; AK122222; BAC65504.1; -; mRNA.
DR   CCDS; CCDS25193.1; -.
DR   RefSeq; NP_080101.1; NM_025825.3.
DR   AlphaFoldDB; Q9DAX9; -.
DR   SMR; Q9DAX9; -.
DR   BioGRID; 211787; 3.
DR   STRING; 10090.ENSMUSP00000018625; -.
DR   iPTMnet; Q9DAX9; -.
DR   PhosphoSitePlus; Q9DAX9; -.
DR   EPD; Q9DAX9; -.
DR   MaxQB; Q9DAX9; -.
DR   PaxDb; Q9DAX9; -.
DR   PeptideAtlas; Q9DAX9; -.
DR   PRIDE; Q9DAX9; -.
DR   ProteomicsDB; 296058; -.
DR   Antibodypedia; 31181; 334 antibodies from 29 providers.
DR   DNASU; 66884; -.
DR   Ensembl; ENSMUST00000018625; ENSMUSP00000018625; ENSMUSG00000018481.
DR   GeneID; 66884; -.
DR   KEGG; mmu:66884; -.
DR   UCSC; uc007krj.1; mouse.
DR   CTD; 10513; -.
DR   MGI; MGI:1914134; Appbp2.
DR   VEuPathDB; HostDB:ENSMUSG00000018481; -.
DR   eggNOG; KOG1840; Eukaryota.
DR   GeneTree; ENSGT00390000010722; -.
DR   HOGENOM; CLU_019378_1_0_1; -.
DR   InParanoid; Q9DAX9; -.
DR   OMA; YAESSHC; -.
DR   OrthoDB; 578212at2759; -.
DR   PhylomeDB; Q9DAX9; -.
DR   TreeFam; TF314010; -.
DR   UniPathway; UPA00143; -.
DR   BioGRID-ORCS; 66884; 2 hits in 72 CRISPR screens.
DR   ChiTaRS; Appbp2; mouse.
DR   PRO; PR:Q9DAX9; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q9DAX9; protein.
DR   Bgee; ENSMUSG00000018481; Expressed in humerus cartilage element and 243 other tissues.
DR   Genevisible; Q9DAX9; MM.
DR   GO; GO:0031462; C:Cul2-RING ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; ISO:MGI.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0046907; P:intracellular transport; ISO:MGI.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR042476; APPBP2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR46575; PTHR46575; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS50005; TPR; 2.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Membrane; Microtubule; Nucleus; Protein transport;
KW   Reference proteome; Repeat; TPR repeat; Transport; Ubl conjugation pathway.
FT   CHAIN           1..585
FT                   /note="Amyloid protein-binding protein 2"
FT                   /id="PRO_0000106260"
FT   REPEAT          50..83
FT                   /note="TPR 1"
FT   REPEAT          120..153
FT                   /note="TPR 2"
FT   REPEAT          206..239
FT                   /note="TPR 3"
FT   REPEAT          288..321
FT                   /note="TPR 4"
FT   REPEAT          333..367
FT                   /note="TPR 5"
FT   REPEAT          429..462
FT                   /note="TPR 6"
FT   REPEAT          471..505
FT                   /note="TPR 7"
FT   REPEAT          514..547
FT                   /note="TPR 8"
SQ   SEQUENCE   585 AA;  66855 MW;  70779B567F785B81 CRC64;
     MAAVELEWIP ETLYNTAISA VVDNYIRSRR DIRSLPENIQ FDVYYKLYQQ GRLCQLGSEF
     CELEVFAKVL RALDKRHLLH HCFQALMDHG VKVASVLAYS FSRRCSYIAE SDAAVKEKAI
     QVGFVLGGFL SDAGWYSDAE KVFLSCLQLC TLHDEMLHWF RAVECCVRLL HVRNGNCKYH
     LGEETFKLAQ TYMDKLSKHG QQANRAALYG ELCALLFAKS HYDEAYKWCV EAMKEITAGL
     PVKVVVDVLR QASKACVVKR EFKKAEQLIK HAVYLARDHF GSKHPKYSDT LLDYGFYLLN
     VDNICQSVAI YQAALDIRQS VFGGKNIHVA TAHEDLAYSS YVHQYSSGKF DNALFHAERA
     IGIITHILPE DHLLLASSKR VKALILEEIA IDCHNKETEQ RLLQEAHDLH LSSLQLAKKA
     FGEFNVQTAK HYGNLGRLYQ SMRKFKEAEE MHIKAIQIKE QLLGQEDYEV ALSVGHLASL
     YNYDMNQYEN AEKLYLRSIA IGKKLFGEGY SGLEYDYRGL IKLYNSIGNY EKVFEYHNVL
     SNWNRLRDRQ YSVTDALEDV SSSPQSTEEV VQSFLMAQNV EGPSC
 
 
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