ID   ICIS_VICFA              Reviewed;          62 AA.
AC   P08820;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Subtilisin inhibitor;
DE   Flags: Fragment;
OS   Vicia faba (Broad bean) (Faba vulgaris).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Fabeae; Vicia.
OX   NCBI_TaxID=3906;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=cv. Kleine Thueringer;
RA   Svendsen I., Hejgaard J., Chavan J.K.;
RT   "Subtilisin inhibitor from seeds of broad bean (Vicia faba); purification,
RT   amino acid sequence and specificity of inhibition.";
RL   Carlsberg Res. Commun. 49:493-502(1984).
CC   -!- FUNCTION: Inhibits subtilisin and more weakly elastase.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I13 (potato type I serine
CC       protease inhibitor) family. {ECO:0000305}.
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DR   PIR; A21463; A21463.
DR   AlphaFoldDB; P08820; -.
DR   SMR; P08820; -.
DR   MEROPS; I13.007; -.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0009611; P:response to wounding; IEA:InterPro.
DR   InterPro; IPR000864; Prot_inh_pot1.
DR   InterPro; IPR036354; Prot_inh_pot1_sf.
DR   PANTHER; PTHR33091; PTHR33091; 1.
DR   Pfam; PF00280; potato_inhibit; 1.
DR   PRINTS; PR00292; POTATOINHBTR.
DR   SUPFAM; SSF54654; SSF54654; 1.
DR   PROSITE; PS00285; POTATO_INHIBITOR; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Protease inhibitor; Serine protease inhibitor.
FT   CHAIN           <1..62
FT                   /note="Subtilisin inhibitor"
FT                   /id="PRO_0000217654"
FT   SITE            38..39
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
FT   VARIANT         22
FT                   /note="M -> K"
FT   VARIANT         33
FT                   /note="D -> G"
FT   NON_TER         1
SQ   SEQUENCE   62 AA;  7064 MW;  CF228E6AA37987EE CRC64;
     RTSWPELVGV SAEEARKIKE EMPEAEIQVV PQDSFVTADY KFQRVRLYVD ESNKVVRAAP
     IG