ICI_LUMTE
ID ICI_LUMTE Reviewed; 86 AA.
AC P83472; Q5UD33;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 2.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=Chymotrypsin inhibitor;
DE Short=LTCI;
DE Flags: Precursor;
OS Lumbricus terrestris (Common earthworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Oligochaeta; Crassiclitellata; Lumbricina; Lumbricidae; Lumbricinae;
OC Lumbricus.
OX NCBI_TaxID=6398;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 23-86, FUNCTION, SUBUNIT,
RP AND TISSUE SPECIFICITY.
RX PubMed=16469515; DOI=10.1016/j.cbpb.2005.12.023;
RA Wojtaszek J., Kolaczkowska A., Kowalska J., Nowak K., Wilusz T.;
RT "LTCI, a novel chymotrypsin inhibitor of the potato I family from the
RT earthworm Lumbricus terrestris. Purification, cDNA cloning, and
RT expression.";
RL Comp. Biochem. Physiol. 143B:465-472(2006).
CC -!- FUNCTION: Inhibits L.terrestris digestive chymotrypsin LT_CH 1 and
CC bovine alpha-chymotrypsin. {ECO:0000269|PubMed:16469515}.
CC -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:16469515}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the body wall, coelomocytes and at a
CC lower level in intestine. {ECO:0000269|PubMed:16469515}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I13 (potato type I serine
CC protease inhibitor) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY756179; AAV35366.1; -; mRNA.
DR AlphaFoldDB; P83472; -.
DR SMR; P83472; -.
DR MEROPS; I13.015; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0009611; P:response to wounding; IEA:InterPro.
DR InterPro; IPR000864; Prot_inh_pot1.
DR InterPro; IPR036354; Prot_inh_pot1_sf.
DR PANTHER; PTHR33091; PTHR33091; 1.
DR Pfam; PF00280; potato_inhibit; 1.
DR PRINTS; PR00292; POTATOINHBTR.
DR SUPFAM; SSF54654; SSF54654; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Protease inhibitor; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:16469515"
FT CHAIN 23..86
FT /note="Chymotrypsin inhibitor"
FT /id="PRO_0000025291"
FT SITE 62..63
FT /note="Reactive bond"
FT /evidence="ECO:0000250"
SQ SEQUENCE 86 AA; 9366 MW; 5C2AAFA40D8D482E CRC64;
MKLLFAIVAL LALAFLCADI SAVKTSWPEL VGETLEEAKA QILEDRPDAV IKVQPEHSPV
TYDYRPSRVI IFVNKDGNVA ETPAAG