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ICI_LUMTE
ID   ICI_LUMTE               Reviewed;          86 AA.
AC   P83472; Q5UD33;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Chymotrypsin inhibitor;
DE            Short=LTCI;
DE   Flags: Precursor;
OS   Lumbricus terrestris (Common earthworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Oligochaeta; Crassiclitellata; Lumbricina; Lumbricidae; Lumbricinae;
OC   Lumbricus.
OX   NCBI_TaxID=6398;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 23-86, FUNCTION, SUBUNIT,
RP   AND TISSUE SPECIFICITY.
RX   PubMed=16469515; DOI=10.1016/j.cbpb.2005.12.023;
RA   Wojtaszek J., Kolaczkowska A., Kowalska J., Nowak K., Wilusz T.;
RT   "LTCI, a novel chymotrypsin inhibitor of the potato I family from the
RT   earthworm Lumbricus terrestris. Purification, cDNA cloning, and
RT   expression.";
RL   Comp. Biochem. Physiol. 143B:465-472(2006).
CC   -!- FUNCTION: Inhibits L.terrestris digestive chymotrypsin LT_CH 1 and
CC       bovine alpha-chymotrypsin. {ECO:0000269|PubMed:16469515}.
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:16469515}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the body wall, coelomocytes and at a
CC       lower level in intestine. {ECO:0000269|PubMed:16469515}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I13 (potato type I serine
CC       protease inhibitor) family. {ECO:0000305}.
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DR   EMBL; AY756179; AAV35366.1; -; mRNA.
DR   AlphaFoldDB; P83472; -.
DR   SMR; P83472; -.
DR   MEROPS; I13.015; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0009611; P:response to wounding; IEA:InterPro.
DR   InterPro; IPR000864; Prot_inh_pot1.
DR   InterPro; IPR036354; Prot_inh_pot1_sf.
DR   PANTHER; PTHR33091; PTHR33091; 1.
DR   Pfam; PF00280; potato_inhibit; 1.
DR   PRINTS; PR00292; POTATOINHBTR.
DR   SUPFAM; SSF54654; SSF54654; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Protease inhibitor; Secreted;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000269|PubMed:16469515"
FT   CHAIN           23..86
FT                   /note="Chymotrypsin inhibitor"
FT                   /id="PRO_0000025291"
FT   SITE            62..63
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   86 AA;  9366 MW;  5C2AAFA40D8D482E CRC64;
     MKLLFAIVAL LALAFLCADI SAVKTSWPEL VGETLEEAKA QILEDRPDAV IKVQPEHSPV
     TYDYRPSRVI IFVNKDGNVA ETPAAG
 
 
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