ICK10_TRILK
ID ICK10_TRILK Reviewed; 116 AA.
AC W4VS46;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 19-MAR-2014, sequence version 1.
DT 25-MAY-2022, entry version 13.
DE RecName: Full=Toxin ICK-10;
DE Flags: Precursor;
OS Trittame loki (Brush-footed trapdoor spider).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Mygalomorphae; Barychelidae; Trittame.
OX NCBI_TaxID=1295018;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=24351713; DOI=10.3390/toxins5122488;
RA Undheim E.A., Sunagar K., Herzig V., Kely L., Low D.H., Jackson T.N.,
RA Jones A., Kurniawan N., King G.F., Ali S.A., Antunes A., Ruder T.,
RA Fry B.G.;
RT "A proteomics and transcriptomics investigation of the venom from the
RT barychelid spider Trittame loki (brush-foot trapdoor).";
RL Toxins 5:2488-2503(2013).
CC -!- FUNCTION: Ion channel inhibitor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the neurotoxin 25 family. ICK-8 subfamily.
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DR EMBL; GAQE01000013; JAB84541.1; -; Transcribed_RNA.
DR AlphaFoldDB; W4VS46; -.
DR ArachnoServer; AS002002; U1-barytoxin-Tl1b.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Disulfide bond; Ion channel impairing toxin; Knottin; Secreted; Signal;
KW Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..116
FT /note="Toxin ICK-10"
FT /id="PRO_0000429217"
FT DISULFID 56..71
FT /evidence="ECO:0000250"
FT DISULFID 64..77
FT /evidence="ECO:0000250"
FT DISULFID 68..113
FT /evidence="ECO:0000250"
FT DISULFID 70..84
FT /evidence="ECO:0000250"
SQ SEQUENCE 116 AA; 12797 MW; 20797637CB8858C2 CRC64;
MMKLYSLVII ATLAAAAFAA TKQEIAAAAL SGMVHDFEQY AKRAEGEEEP KRYIRCSKQL
GEKCDLNCEC CGASAVCEDY NYICKEKVSD NPVLDWFGQG LNAMGNAISR YYCDAE