APC10_ARATH
ID APC10_ARATH Reviewed; 192 AA.
AC Q9ZPW2; Q1WWJ4; Q8LBL8;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 25-MAY-2022, entry version 139.
DE RecName: Full=Anaphase-promoting complex subunit 10;
DE Short=APC10;
DE AltName: Full=Cyclosome subunit 10;
GN Name=APC10; OrderedLocusNames=At2g18290; ORFNames=T30D6.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP INTERACTION WITH CDC27A AND CDC27B.
RX PubMed=17944809; DOI=10.1111/j.1365-313x.2007.03312.x;
RA Perez-Perez J.M., Serralbo O., Vanstraelen M., Gonzalez C., Criqui M.C.,
RA Genschik P., Kondorosi E., Scheres B.;
RT "Specialization of CDC27 function in the Arabidopsis thaliana anaphase-
RT promoting complex (APC/C).";
RL Plant J. 53:78-89(2008).
RN [7]
RP REVIEW, AND GENE FAMILY.
RX PubMed=21087491; DOI=10.1186/1471-2229-10-254;
RA Lima M.D.F., Eloy N.B., Pegoraro C., Sagit R., Rojas C., Bretz T.,
RA Vargas L., Elofsson A., de Oliveira A.C., Hemerly A.S., Ferreira P.C.G.;
RT "Genomic evolution and complexity of the Anaphase-promoting Complex (APC)
RT in land plants.";
RL BMC Plant Biol. 10:254-254(2010).
RN [8]
RP INTERACTION WITH CDC20-1 AND CDC20-2.
RX PubMed=21687678; DOI=10.1371/journal.pone.0020618;
RA Kevei Z., Baloban M., Da Ines O., Tiricz H., Kroll A., Regulski K.,
RA Mergaert P., Kondorosi E.;
RT "Conserved CDC20 cell cycle functions are carried out by two of the five
RT isoforms in Arabidopsis thaliana.";
RL PLoS ONE 6:E20618-E20618(2011).
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle. The APC/C complex controls several key steps in the cell cycle
CC by mediating the ubiquitination and subsequent degradation of target
CC proteins such as cyclins. The APC/C complex is required for the female
CC gametophyte development and is involved in several other aspects of
CC development. Involved in the control of endoreduplication.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Component of the anaphase promoting complex/cyclosome (APC/C),
CC which is composed of at least 10 subunits. Interacts with CDC20-1,
CC CDC20-2, CDC27A and CDC27B. {ECO:0000269|PubMed:17944809,
CC ECO:0000269|PubMed:21687678}.
CC -!- INTERACTION:
CC Q9ZPW2; Q06AN9: CDC27A; NbExp=3; IntAct=EBI-1749354, EBI-1749373;
CC Q9ZPW2; Q8LGU6: CDC27B; NbExp=3; IntAct=EBI-1749354, EBI-1668733;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the APC10 family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Arabidopsis APC/C subunits;
CC URL="http://personal.rhul.ac.uk/ujba/110/apc/APC.htm";
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DR EMBL; AC006439; AAD15507.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC06751.1; -; Genomic_DNA.
DR EMBL; AY087130; AAM64688.1; -; mRNA.
DR EMBL; BT024912; ABD94068.1; -; mRNA.
DR EMBL; AK229538; BAF01391.1; -; mRNA.
DR PIR; F84562; F84562.
DR RefSeq; NP_565433.1; NM_127387.3.
DR AlphaFoldDB; Q9ZPW2; -.
DR SMR; Q9ZPW2; -.
DR BioGRID; 1702; 22.
DR IntAct; Q9ZPW2; 20.
DR STRING; 3702.AT2G18290.1; -.
DR iPTMnet; Q9ZPW2; -.
DR PaxDb; Q9ZPW2; -.
DR PRIDE; Q9ZPW2; -.
DR ProteomicsDB; 224557; -.
DR EnsemblPlants; AT2G18290.1; AT2G18290.1; AT2G18290.
DR GeneID; 816345; -.
DR Gramene; AT2G18290.1; AT2G18290.1; AT2G18290.
DR KEGG; ath:AT2G18290; -.
DR Araport; AT2G18290; -.
DR TAIR; locus:2062106; AT2G18290.
DR eggNOG; KOG3437; Eukaryota.
DR HOGENOM; CLU_039415_3_0_1; -.
DR InParanoid; Q9ZPW2; -.
DR OMA; FITIEFP; -.
DR OrthoDB; 1588694at2759; -.
DR PhylomeDB; Q9ZPW2; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9ZPW2; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZPW2; baseline and differential.
DR Genevisible; Q9ZPW2; AT.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0016604; C:nuclear body; IDA:TAIR.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IMP:TAIR.
DR GO; GO:0032876; P:negative regulation of DNA endoreduplication; IMP:TAIR.
DR GO; GO:0010087; P:phloem or xylem histogenesis; IMP:TAIR.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR GO; GO:0032875; P:regulation of DNA endoreduplication; IMP:TAIR.
DR CDD; cd08366; APC10; 1.
DR InterPro; IPR016901; APC10/Doc1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR12936; PTHR12936; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR PIRSF; PIRSF028841; APC10_sub; 1.
DR SMART; SM01337; APC10; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR PROSITE; PS51284; DOC; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome;
KW Ubl conjugation pathway.
FT CHAIN 1..192
FT /note="Anaphase-promoting complex subunit 10"
FT /id="PRO_0000174014"
FT DOMAIN 6..192
FT /note="DOC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00614"
FT CONFLICT 112
FT /note="E -> D (in Ref. 3; AAM64688)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 192 AA; 21750 MW; 5ADBE0E8F7D12FFC CRC64;
MATESSESEE EGKISGGNYK LIIDDDLREM GKNAAWSVSS CKPGNGVTTL RDDNLETYWQ
SDGLQPHLIN IQFQKKVKLQ LVVLYVDFKL DESYTPSKIS IRAGDGFHNL KEIKSVELVK
PTGWVCLSLS GTDPRETFVN TFMLQIAILS NHLNGRDTHI RQIKVYGPRP NPIPHQPFQF
TSMEFLTYST LR
