ID   APC10_BOVIN             Reviewed;         185 AA.
AC   Q2YDH1;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Anaphase-promoting complex subunit 10;
DE            Short=APC10;
DE   AltName: Full=Cyclosome subunit 10;
GN   Name=ANAPC10; Synonyms=APC10;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC       progression through mitosis and the G1 phase of the cell cycle. The
CC       APC/C complex acts by mediating ubiquitination and subsequent
CC       degradation of target proteins: it mainly mediates the formation of
CC       'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC       formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By
CC       similarity). {ECO:0000250|UniProtKB:Q9UM13}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: The mammalian APC/C is composed at least of 14 distinct
CC       subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6,
CC       ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and
CC       ANAPC16 that assemble into a complex of at least 19 chains with a
CC       combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1
CC       and FBXO5. The C-terminus of APC10 binds to CDC27/APC3 (By similarity).
CC       Interacts with PIWIL1; interaction only takes place when PIWIL1 binds
CC       piRNA (By similarity). {ECO:0000250|UniProtKB:Q8K2H6,
CC       ECO:0000250|UniProtKB:Q9UM13}.
CC   -!- SIMILARITY: Belongs to the APC10 family. {ECO:0000305}.
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DR   EMBL; BC110224; AAI10225.1; -; mRNA.
DR   RefSeq; NP_001073826.1; NM_001080357.2.
DR   AlphaFoldDB; Q2YDH1; -.
DR   SMR; Q2YDH1; -.
DR   STRING; 9913.ENSBTAP00000017721; -.
DR   PaxDb; Q2YDH1; -.
DR   GeneID; 783986; -.
DR   KEGG; bta:783986; -.
DR   CTD; 10393; -.
DR   eggNOG; KOG3437; Eukaryota.
DR   InParanoid; Q2YDH1; -.
DR   OrthoDB; 804390at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
DR   CDD; cd08366; APC10; 1.
DR   InterPro; IPR016901; APC10/Doc1.
DR   InterPro; IPR004939; APC_su10/DOC_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR12936; PTHR12936; 1.
DR   Pfam; PF03256; ANAPC10; 1.
DR   PIRSF; PIRSF028841; APC10_sub; 1.
DR   SMART; SM01337; APC10; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   PROSITE; PS51284; DOC; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell cycle; Cell division; Mitosis; Reference proteome;
KW   Ubl conjugation pathway.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UM13"
FT   CHAIN           2..185
FT                   /note="Anaphase-promoting complex subunit 10"
FT                   /id="PRO_0000345959"
FT   DOMAIN          2..185
FT                   /note="DOC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00614"
FT   MOD_RES         2
FT                   /note="N-acetylthreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UM13"
FT   MOD_RES         169
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8K2H6"
SQ   SEQUENCE   185 AA;  21252 MW;  0CA2F245B3831FF6 CRC64;
     MTTPNKTPPG ADPKQLERTG TVREIGSQAV WSLSSCKPGF GVDQLRDDNL ETYWQSDGSQ
     PHLVNLQFRR KTTVKTLCIY ADYKSDESYT PSKISVRVGN NFHNLQEIRQ LELVEPSGWI
     HVPLTDNHKK PTRTFMIQIA VLANHQNGRD THMRQIKIYT PVEESSIGKF PRCTTIDFMM
     YRSIR