ICK40_TRILK
ID ICK40_TRILK Reviewed; 114 AA.
AC W4VS08;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 19-MAR-2014, sequence version 1.
DT 25-MAY-2022, entry version 16.
DE RecName: Full=U17-barytoxin-Tl1d;
DE Short=U17-BATX-Tl1d;
DE AltName: Full=Toxin ICK-40 {ECO:0000303|PubMed:24351713};
DE Flags: Precursor;
OS Trittame loki (Brush-footed trapdoor spider).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Mygalomorphae; Barychelidae; Trittame.
OX NCBI_TaxID=1295018;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=24351713; DOI=10.3390/toxins5122488;
RA Undheim E.A., Sunagar K., Herzig V., Kely L., Low D.H., Jackson T.N.,
RA Jones A., Kurniawan N., King G.F., Ali S.A., Antunes A., Ruder T.,
RA Fry B.G.;
RT "A proteomics and transcriptomics investigation of the venom from the
RT barychelid spider Trittame loki (brush-foot trapdoor).";
RL Toxins 5:2488-2503(2013).
CC -!- FUNCTION: Ion channel inhibitor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the neurotoxin 14 (magi-1) family. 03 (ICK-30-
CC 40) subfamily. {ECO:0000305}.
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DR EMBL; GAQE01000043; JAB84511.1; -; Transcribed_RNA.
DR AlphaFoldDB; W4VS08; -.
DR ArachnoServer; AS001785; U17-barytoxin-Tl1d.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019871; F:sodium channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR012627; Toxin_22.
DR Pfam; PF08092; Toxin_22; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond;
KW Ion channel impairing toxin; Knottin; Secreted; Signal; Toxin.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..74
FT /evidence="ECO:0000305"
FT /id="PRO_0000435163"
FT CHAIN 75..114
FT /note="U17-barytoxin-Tl1d"
FT /id="PRO_0000429247"
FT DISULFID 75..88
FT /evidence="ECO:0000250"
FT DISULFID 82..93
FT /evidence="ECO:0000250"
FT DISULFID 87..108
FT /evidence="ECO:0000250"
SQ SEQUENCE 114 AA; 12961 MW; 6043EE887CA89A8A CRC64;
MKTIIVFLSL LVLATKFGDA NEGVNQEQMK EVIQNEFRED FLNEMAPMSL LQQLEAIEST
LLEKEADRNS RQKRCLGENV PCGDFPCCGK LACEKTFGYG WWYKSPFCVK PSKG