ICLN_ARATH
ID ICLN_ARATH Reviewed; 229 AA.
AC Q9LVA7; B3H4U0;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Chloride conductance regulatory protein ICln;
DE Short=I(Cln);
DE AltName: Full=Chloride ion current inducer protein;
DE Short=ClCI;
GN OrderedLocusNames=At5g62290; ORFNames=MMI9.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May participate in cellular volume control by activation of a
CC swelling-induced chloride conductance pathway. {ECO:0000250}.
CC -!- SUBUNIT: Homooligomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9LVA7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9LVA7-2; Sequence=VSP_042271;
CC -!- SIMILARITY: Belongs to the pICln (TC 1.A.47) family. {ECO:0000305}.
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DR EMBL; AB019235; BAA97193.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97591.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97592.1; -; Genomic_DNA.
DR EMBL; AK119007; BAC43583.1; -; mRNA.
DR EMBL; BT005429; AAO63849.1; -; mRNA.
DR EMBL; AY088500; AAM66035.1; -; mRNA.
DR RefSeq; NP_001119478.1; NM_001126006.1. [Q9LVA7-2]
DR RefSeq; NP_201035.1; NM_125623.3. [Q9LVA7-1]
DR AlphaFoldDB; Q9LVA7; -.
DR SMR; Q9LVA7; -.
DR BioGRID; 21594; 3.
DR IntAct; Q9LVA7; 3.
DR STRING; 3702.AT5G62290.1; -.
DR TCDB; 1.A.47.4.1; the nucleotide-sensitive anion-selective channel, icln (icln) family.
DR iPTMnet; Q9LVA7; -.
DR PaxDb; Q9LVA7; -.
DR PRIDE; Q9LVA7; -.
DR ProteomicsDB; 228760; -. [Q9LVA7-1]
DR EnsemblPlants; AT5G62290.1; AT5G62290.1; AT5G62290. [Q9LVA7-1]
DR EnsemblPlants; AT5G62290.2; AT5G62290.2; AT5G62290. [Q9LVA7-2]
DR GeneID; 836350; -.
DR Gramene; AT5G62290.1; AT5G62290.1; AT5G62290. [Q9LVA7-1]
DR Gramene; AT5G62290.2; AT5G62290.2; AT5G62290. [Q9LVA7-2]
DR KEGG; ath:AT5G62290; -.
DR Araport; AT5G62290; -.
DR TAIR; locus:2167918; AT5G62290.
DR eggNOG; KOG3238; Eukaryota.
DR InParanoid; Q9LVA7; -.
DR OMA; HNPANSI; -.
DR PhylomeDB; Q9LVA7; -.
DR PRO; PR:Q9LVA7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LVA7; baseline and differential.
DR Genevisible; Q9LVA7; AT.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0034709; C:methylosome; IEA:InterPro.
DR GO; GO:0034715; C:pICln-Sm protein complex; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0006884; P:cell volume homeostasis; IEA:InterPro.
DR GO; GO:0006821; P:chloride transport; IEA:InterPro.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; IEA:InterPro.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR003521; ICln.
DR InterPro; IPR039924; ICln/Lot5/Saf5.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR21399; PTHR21399; 1.
DR Pfam; PF03517; Voldacs; 1.
DR PRINTS; PR01348; ICLNCHANNEL.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..229
FT /note="Chloride conductance regulatory protein ICln"
FT /id="PRO_0000415519"
FT VAR_SEQ 154
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_042271"
SQ SEQUENCE 229 AA; 25603 MW; 82A73C1B714675B8 CRC64;
MVAGLRDFTL RTEDGSGKPV LDESNGEELM HVQTSVAVAL GNRPIESPGT LYITSRKLIW
LSDVDMAKGY AVDFLSISLH AVSRDPEAYS SPCIYTQIEV EEDEDDESDS ESTEVLDLSK
IREMRLVPSD STQLETLFDV FCECAELNPE PVQEEEEESG HNWVFSADQM DVRGGDDDAE
WQISQSPTSV IGHSNGDEGL NQPMLELQIN DQRFEDAEEM VHESETKDH
