APC10_CAEEL
ID APC10_CAEEL Reviewed; 212 AA.
AC H2L2B8; Q19487;
DT 20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Anaphase-promoting complex subunit 10 {ECO:0000312|WormBase:F15H10.3b};
DE Short=APC10 {ECO:0000312|WormBase:F15H10.3b};
GN Name=apc-10 {ECO:0000312|WormBase:F15H10.3b};
GN ORFNames=F15H10.3 {ECO:0000312|WormBase:F15H10.3b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=11861581; DOI=10.1093/genetics/160.2.805;
RA Davis E.S., Wille L., Chestnut B.A., Sadler P.L., Shakes D.C., Golden A.;
RT "Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex
RT are required for chromosome segregation during meiosis I.";
RL Genetics 160:805-813(2002).
CC -!- FUNCTION: Probable component of the anaphase promoting
CC complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle. The APC/C complex acts by mediating ubiquitination and
CC subsequent degradation of target proteins.
CC {ECO:0000269|PubMed:11861581}.
CC -!- PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305}.
CC -!- SUBUNIT: The APC/C complex is probably composed of at least 12
CC subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1,
CC mat-2, mat-3, such-1 and gfi-3. {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:F15H10.3a};
CC IsoId=H2L2B8-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:F15H10.3b};
CC IsoId=H2L2B8-2; Sequence=VSP_058036;
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in both viable
CC and inviable embryos, but eventually animals display germline
CC maintenance defects and become sterile. {ECO:0000269|PubMed:11861581}.
CC -!- SIMILARITY: Belongs to the APC10 family. {ECO:0000305}.
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DR EMBL; Z73972; CCE71794.1; -; Genomic_DNA.
DR EMBL; Z73972; CCE71795.1; -; Genomic_DNA.
DR EMBL; Z73972; CCE71796.1; -; Genomic_DNA.
DR EMBL; Z73972; CAA98261.2; -; Genomic_DNA.
DR PIR; T20998; T20998.
DR RefSeq; NP_001256217.1; NM_001269288.1. [H2L2B8-1]
DR RefSeq; NP_001256218.1; NM_001269289.1. [H2L2B8-1]
DR RefSeq; NP_001256219.1; NM_001269290.1. [H2L2B8-1]
DR RefSeq; NP_001256220.1; NM_001269291.1. [H2L2B8-2]
DR AlphaFoldDB; H2L2B8; -.
DR SMR; H2L2B8; -.
DR ComplexPortal; CPX-3382; Anaphase Promoting Complex/Cyclosome.
DR STRING; 6239.F15H10.3b; -.
DR EPD; H2L2B8; -.
DR PaxDb; H2L2B8; -.
DR EnsemblMetazoa; F15H10.3a.1; F15H10.3a.1; WBGene00000144. [H2L2B8-2]
DR EnsemblMetazoa; F15H10.3b.1; F15H10.3b.1; WBGene00000144. [H2L2B8-1]
DR EnsemblMetazoa; F15H10.3c.1; F15H10.3c.1; WBGene00000144. [H2L2B8-1]
DR EnsemblMetazoa; F15H10.3d.1; F15H10.3d.1; WBGene00000144. [H2L2B8-1]
DR GeneID; 179454; -.
DR KEGG; cel:CELE_F15H10.3; -.
DR UCSC; F15H10.3.1; c. elegans.
DR CTD; 179454; -.
DR WormBase; F15H10.3a; CE40942; WBGene00000144; apc-10. [H2L2B8-2]
DR WormBase; F15H10.3b; CE46558; WBGene00000144; apc-10. [H2L2B8-1]
DR WormBase; F15H10.3c; CE46558; WBGene00000144; apc-10. [H2L2B8-1]
DR WormBase; F15H10.3d; CE46558; WBGene00000144; apc-10. [H2L2B8-1]
DR eggNOG; KOG3437; Eukaryota.
DR GeneTree; ENSGT00390000013722; -.
DR InParanoid; H2L2B8; -.
DR OMA; HEKGRDC; -.
DR OrthoDB; 1588694at2759; -.
DR PhylomeDB; H2L2B8; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:H2L2B8; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00000144; Expressed in germ line (C elegans) and 3 other tissues.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IC:ComplexPortal.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR GO; GO:0051445; P:regulation of meiotic cell cycle; IC:ComplexPortal.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IC:ComplexPortal.
DR GO; GO:1904666; P:regulation of ubiquitin protein ligase activity; IC:ComplexPortal.
DR CDD; cd08366; APC10; 1.
DR InterPro; IPR016901; APC10/Doc1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR12936; PTHR12936; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR SMART; SM01337; APC10; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR PROSITE; PS51284; DOC; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Cell cycle; Cell division; Developmental protein;
KW Meiosis; Mitosis; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..212
FT /note="Anaphase-promoting complex subunit 10"
FT /evidence="ECO:0000305"
FT /id="PRO_0000435325"
FT DOMAIN 12..196
FT /note="DOC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00614"
FT VAR_SEQ 1..11
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_058036"
SQ SEQUENCE 212 AA; 24783 MW; 2309A47B02247BD8 CRC64;
MLADHQIPEQ SMDEEERTSS RGWMREFKYP SNLRDITEEA RISLSSVAHC GGVDELLHES
SELAWRTNMS PPHRALFTFS KKTDISYVML FLDYSRDESY CPQEVRIDLG DGTNDWWLKM
YRRVDQPKGW VKIPIHDAFG NPLRVMSLQM TIMKNHEKGR DCVVRHFRVL GPFRSRYDSM
NRMILGPSAV LEARPGTEPI KDAIMNHYQS MR
