ICLR_SALTY
ID ICLR_SALTY Reviewed; 274 AA.
AC P17430;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Acetate operon repressor;
GN Name=iclR; OrderedLocusNames=STM4187;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2194169; DOI=10.1093/nar/18.12.3656;
RA Galinier A., Negre D., Cortay J.-C., Marcandier S., Maloy S.R.,
RA Cozzone A.J.;
RT "Sequence analysis of the iclR gene encoding the repressor of the acetate
RT operon in Salmonella typhimurium.";
RL Nucleic Acids Res. 18:3656-3656(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Regulation of the glyoxylate bypass operon, which encodes
CC isocitrate lyase, malate synthase as well as isocitrate dehydrogenase
CC kinase/phosphorylase.
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DR EMBL; X52950; CAA37126.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL23011.1; -; Genomic_DNA.
DR PIR; S12729; S12729.
DR RefSeq; NP_463052.1; NC_003197.2.
DR RefSeq; WP_000226434.1; NC_003197.2.
DR AlphaFoldDB; P17430; -.
DR SMR; P17430; -.
DR STRING; 99287.STM4187; -.
DR PaxDb; P17430; -.
DR EnsemblBacteria; AAL23011; AAL23011; STM4187.
DR GeneID; 1255713; -.
DR KEGG; stm:STM4187; -.
DR PATRIC; fig|99287.12.peg.4400; -.
DR HOGENOM; CLU_062618_7_1_6; -.
DR OMA; EPDRLHR; -.
DR PhylomeDB; P17430; -.
DR BioCyc; SENT99287:STM4187-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF09339; HTH_IclR; 1.
DR Pfam; PF01614; IclR; 1.
DR SMART; SM00346; HTH_ICLR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51077; HTH_ICLR; 1.
DR PROSITE; PS51078; ICLR_ED; 1.
PE 4: Predicted;
KW DNA-binding; Glyoxylate bypass; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..274
FT /note="Acetate operon repressor"
FT /id="PRO_0000201759"
FT DOMAIN 24..86
FT /note="HTH iclR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT DOMAIN 101..272
FT /note="IclR-ED"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00394"
FT DNA_BIND 46..65
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 160..161
FT /ligand="glyoxylate"
FT /ligand_id="ChEBI:CHEBI:36655"
FT /evidence="ECO:0000250"
FT BINDING 212
FT /ligand="glyoxylate"
FT /ligand_id="ChEBI:CHEBI:36655"
FT /evidence="ECO:0000250"
FT BINDING 222
FT /ligand="glyoxylate"
FT /ligand_id="ChEBI:CHEBI:36655"
FT /evidence="ECO:0000250"
FT BINDING 239..241
FT /ligand="glyoxylate"
FT /ligand_id="ChEBI:CHEBI:36655"
FT /evidence="ECO:0000250"
FT CONFLICT 43
FT /note="S -> T (in Ref. 1; CAA37126)"
FT /evidence="ECO:0000305"
FT CONFLICT 59
FT /note="T -> S (in Ref. 1; CAA37126)"
FT /evidence="ECO:0000305"
FT CONFLICT 86
FT /note="A -> P (in Ref. 1; CAA37126)"
FT /evidence="ECO:0000305"
FT CONFLICT 152..157
FT /note="GKLPMH -> ASCPMP (in Ref. 1; CAA37126)"
FT /evidence="ECO:0000305"
FT CONFLICT 205
FT /note="R -> A (in Ref. 1; CAA37126)"
FT /evidence="ECO:0000305"
FT CONFLICT 244
FT /note="C -> R (in Ref. 1; CAA37126)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 274 AA; 29614 MW; 0A860F6107C95C92 CRC64;
MVAPVPAKRG RKPAATTAPV TGQVQSLTRG LKLLEWIAES NGSVALTELA QQAGLPNSTT
HRLLTTMQQQ GFVRQVGELG HWAVGAHAFI VGSSFLQSRN LLAIVHPILR KLMEDSGETV
NLAVLDQSDH QAIIIDQVQC TQLMRMSAPI GGKLPMHASG AGKAFLSQLS EEQVTSLLHR
KGLHAYTHAT LVSPLHLKDD LAQTRKRGYS FDDEEHALGL RCVASCIYDE HREPFAALSI
SGPCSRITDD RVTELGAMVI KAAKEVTLAY GGTR
