APC10_DROME
ID APC10_DROME Reviewed; 195 AA.
AC Q9V831; Q8MTU6;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 29-AUG-2003, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Anaphase-promoting complex subunit 10;
DE Short=APC10;
DE AltName: Full=Cyclosome subunit 10;
GN Name=APC10; ORFNames=CG11419;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated ubiquitin ligase that controls
CC progression through mitosis and the G1 phase of the cell cycle.
CC {ECO:0000250}.
CC -!- SUBUNIT: The APC is composed of at least 11 subunits. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the APC10 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF57848.2; -; Genomic_DNA.
DR EMBL; AY071207; AAL48829.2; -; mRNA.
DR RefSeq; NP_611223.4; NM_137379.5.
DR AlphaFoldDB; Q9V831; -.
DR SMR; Q9V831; -.
DR BioGRID; 62667; 4.
DR DIP; DIP-19814N; -.
DR IntAct; Q9V831; 3.
DR STRING; 7227.FBpp0086107; -.
DR PaxDb; Q9V831; -.
DR DNASU; 36975; -.
DR EnsemblMetazoa; FBtr0086951; FBpp0086107; FBgn0034231.
DR GeneID; 36975; -.
DR KEGG; dme:Dmel_CG11419; -.
DR UCSC; CG11419-RA; d. melanogaster.
DR CTD; 36975; -.
DR FlyBase; FBgn0034231; APC10.
DR VEuPathDB; VectorBase:FBgn0034231; -.
DR eggNOG; KOG3437; Eukaryota.
DR GeneTree; ENSGT00390000013722; -.
DR HOGENOM; CLU_039415_3_0_1; -.
DR InParanoid; Q9V831; -.
DR OMA; FITIEFP; -.
DR OrthoDB; 1588694at2759; -.
DR PhylomeDB; Q9V831; -.
DR Reactome; R-DME-141430; Inactivation of APC/C via direct inhibition of the APC/C complex.
DR Reactome; R-DME-174048; APC/C:Cdc20 mediated degradation of Cyclin B.
DR Reactome; R-DME-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR Reactome; R-DME-174154; APC/C:Cdc20 mediated degradation of Securin.
DR Reactome; R-DME-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR Reactome; R-DME-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR Reactome; R-DME-176407; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
DR Reactome; R-DME-176408; Regulation of APC/C activators between G1/S and early anaphase.
DR Reactome; R-DME-176409; APC/C:Cdc20 mediated degradation of mitotic proteins.
DR Reactome; R-DME-176412; Phosphorylation of the APC/C.
DR Reactome; R-DME-179409; APC-Cdc20 mediated degradation of Nek2A.
DR Reactome; R-DME-2467813; Separation of Sister Chromatids.
DR Reactome; R-DME-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR Reactome; R-DME-68867; Assembly of the pre-replicative complex.
DR Reactome; R-DME-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-DME-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR BioGRID-ORCS; 36975; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 36975; -.
DR PRO; PR:Q9V831; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034231; Expressed in eye disc (Drosophila) and 20 other tissues.
DR Genevisible; Q9V831; DM.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007113; P:endomitotic cell cycle; IGI:FlyBase.
DR GO; GO:0000278; P:mitotic cell cycle; HMP:FlyBase.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR GO; GO:2000736; P:regulation of stem cell differentiation; IMP:FlyBase.
DR CDD; cd08366; APC10; 1.
DR InterPro; IPR016901; APC10/Doc1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR12936; PTHR12936; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR PIRSF; PIRSF028841; APC10_sub; 1.
DR SMART; SM01337; APC10; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR PROSITE; PS51284; DOC; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Mitosis; Reference proteome;
KW Ubl conjugation pathway.
FT CHAIN 1..195
FT /note="Anaphase-promoting complex subunit 10"
FT /id="PRO_0000174013"
FT DOMAIN 9..193
FT /note="DOC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00614"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 195 AA; 22300 MW; 4247D1524CE2AF49 CRC64;
MAASMDEDIT ANPPPSSEED PLAEERLGFV REVGAQAVWS LSSCKPGFGV ERLRDNIMDT
YWQSDGQLPH LVNIQFHKRT NISQIYIYTD YKLDESYTPS RISIRSGTNF NDLQELQVMD
LTEPTGWVQI PIKDGNVKSI RTFMLQIAVI SNHQNGRDTH MRQIRIHAPV EGKHYPLELF
GKFGTVDFQK FATIR
