位置:首页 > 蛋白库 > ICOSL_HUMAN
ICOSL_HUMAN
ID   ICOSL_HUMAN             Reviewed;         302 AA.
AC   O75144; A8MUZ1; Q9HD18; Q9NRQ1;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   14-AUG-2001, sequence version 2.
DT   03-AUG-2022, entry version 194.
DE   RecName: Full=ICOS ligand;
DE   AltName: Full=B7 homolog 2;
DE            Short=B7-H2;
DE   AltName: Full=B7-like protein Gl50;
DE   AltName: Full=B7-related protein 1;
DE            Short=B7RP-1;
DE   AltName: CD_antigen=CD275;
DE   Flags: Precursor;
GN   Name=ICOSLG; Synonyms=B7H2, B7RP1, ICOSL, KIAA0653;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Dendritic cell;
RX   PubMed=11023515;
RA   Wang S., Zhu G., Chapoval A.I., Dong H., Tamada K., Ni J., Chen L.;
RT   "Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS.";
RL   Blood 96:2808-2813(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, AND SUBCELLULAR
RP   LOCATION.
RC   TISSUE=Peripheral blood lymphocyte;
RX   PubMed=11007762; DOI=10.1093/intimm/12.10.1439;
RA   Yoshinaga S.K., Zhang M., Pistillo J., Horan T., Khare S.D., Miner K.,
RA   Sonnenberg M., Boone T., Brankow D., Dai T., Delaney J., Han H., Hui A.,
RA   Kohno T., Manoukian R., Whoriskey J.S., Coccia M.A.;
RT   "Characterization of a new human B7-related protein: B7RP-1 is the ligand
RT   to the co-stimulatory protein ICOS.";
RL   Int. Immunol. 12:1439-1447(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC   TISSUE=Leukocyte;
RX   PubMed=10657606; DOI=10.4049/jimmunol.164.4.1653;
RA   Ling V., Wu P.W., Finnerty H.F., Bean K.M., Spaulding V., Fouser L.A.,
RA   Leonard J.P., Hunter S.E., Zollner R., Thomas J.L., Miyashiro J.S.,
RA   Jacobs K.A., Collins M.;
RT   "Identification of GL50, a novel B7-like protein that functionally binds to
RT   ICOS receptor.";
RL   J. Immunol. 164:1653-1657(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA   Ling V., Dunussi-Joannopolulos K.;
RT   "GL50 molecules and uses therefor.";
RL   Patent number WO0121796, 29-MAR-2001.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=9734811; DOI=10.1093/dnares/5.3.169;
RA   Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H.,
RA   Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. X. The
RT   complete sequences of 100 new cDNA clones from brain which can code for
RT   large proteins in vitro.";
RL   DNA Res. 5:169-176(1998).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA   Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA   Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA   Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA   Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA   Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA   Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA   Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA   Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA   Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA   Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [10]
RP   TISSUE SPECIFICITY.
RX   PubMed=10779774; DOI=10.4049/jimmunol.164.9.4689;
RA   Aicher A., Hayden-Ledbetter M., Brady W.A., Pezzutto A., Richter G.,
RA   Magaletti D., Buckwalter S., Ledbetter J.A., Clark E.A.;
RT   "Characterization of human inducible costimulator ligand expression and
RT   function.";
RL   J. Immunol. 164:4689-4696(2000).
RN   [11]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-70 AND ASN-186.
RC   TISSUE=Plasma;
RX   PubMed=16335952; DOI=10.1021/pr0502065;
RA   Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J.,
RA   Smith R.D.;
RT   "Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
RT   hydrazide chemistry, and mass spectrometry.";
RL   J. Proteome Res. 4:2070-2080(2005).
RN   [12]
RP   INTERACTION WITH CTLA4.
RX   PubMed=28484017; DOI=10.1073/pnas.1617941114;
RA   Ramagopal U.A., Liu W., Garrett-Thomson S.C., Bonanno J.B., Yan Q.,
RA   Srinivasan M., Wong S.C., Bell A., Mankikar S., Rangan V.S., Deshpande S.,
RA   Korman A.J., Almo S.C.;
RT   "Structural basis for cancer immunotherapy by the first-in-class checkpoint
RT   inhibitor ipilimumab.";
RL   Proc. Natl. Acad. Sci. U.S.A. 114:E4223-E4232(2017).
CC   -!- FUNCTION: Ligand for the T-cell-specific cell surface receptor ICOS.
CC       Acts as a costimulatory signal for T-cell proliferation and cytokine
CC       secretion; induces also B-cell proliferation and differentiation into
CC       plasma cells. Could play an important role in mediating local tissue
CC       responses to inflammatory conditions, as well as in modulating the
CC       secondary immune response by co-stimulating memory T-cell function (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CTLA4 (in vitro).
CC       {ECO:0000269|PubMed:28484017}.
CC   -!- INTERACTION:
CC       O75144; Q9Y6W8: ICOS; NbExp=8; IntAct=EBI-12923856, EBI-3922712;
CC       O75144; O75144: ICOSLG; NbExp=7; IntAct=EBI-12923856, EBI-12923856;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11007762};
CC       Single-pass type I membrane protein {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC         Comment=Additional isoforms seem to exist.;
CC       Name=1;
CC         IsoId=O75144-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O75144-2; Sequence=VSP_002520;
CC       Name=3;
CC         IsoId=O75144-3; Sequence=VSP_054718;
CC   -!- TISSUE SPECIFICITY: Isoform 1 is widely expressed (brain, heart,
CC       kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow,
CC       colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus
CC       and tonsil), while isoform 2 is detected only in lymph nodes,
CC       leukocytes and spleen. Expressed on activated monocytes and dendritic
CC       cells. {ECO:0000269|PubMed:10779774}.
CC   -!- INDUCTION: Constitutive expression is further enhanced by treatment
CC       with TNF in peripheral blood B-cells and monocytes, while it is
CC       decreased in dendritic cells.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA31628.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAA31628.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown in position 300 onward for unknown reason.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF199028; AAF34739.1; -; mRNA.
DR   EMBL; AF289028; AAG01176.1; -; mRNA.
DR   EMBL; AF216749; AAK16241.1; -; mRNA.
DR   EMBL; AX100595; CAC36465.1; -; mRNA.
DR   EMBL; AB014553; BAA31628.1; ALT_SEQ; mRNA.
DR   EMBL; AK090492; BAG52170.1; -; mRNA.
DR   EMBL; AP001058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471079; EAX09446.1; -; Genomic_DNA.
DR   EMBL; BC064637; AAH64637.1; -; mRNA.
DR   CCDS; CCDS42952.1; -. [O75144-1]
DR   CCDS; CCDS63377.1; -. [O75144-3]
DR   CCDS; CCDS63379.1; -. [O75144-2]
DR   RefSeq; NP_001269979.1; NM_001283050.1. [O75144-2]
DR   RefSeq; NP_001269980.1; NM_001283051.1. [O75144-3]
DR   RefSeq; NP_056074.1; NM_015259.5. [O75144-1]
DR   RefSeq; XP_006723963.1; XM_006723900.2.
DR   PDB; 6X4G; X-ray; 3.50 A; C=19-248.
DR   PDB; 6X4T; X-ray; 3.15 A; A/C=19-248.
DR   PDBsum; 6X4G; -.
DR   PDBsum; 6X4T; -.
DR   AlphaFoldDB; O75144; -.
DR   SMR; O75144; -.
DR   BioGRID; 116900; 21.
DR   IntAct; O75144; 7.
DR   ChEMBL; CHEMBL3712949; -.
DR   GlyConnect; 740; 5 N-Linked glycans (3 sites).
DR   GlyGen; O75144; 6 sites, 7 N-linked glycans (3 sites).
DR   iPTMnet; O75144; -.
DR   PhosphoSitePlus; O75144; -.
DR   SwissPalm; O75144; -.
DR   BioMuta; ICOSLG; -.
DR   CPTAC; CPTAC-2600; -.
DR   EPD; O75144; -.
DR   jPOST; O75144; -.
DR   MassIVE; O75144; -.
DR   MaxQB; O75144; -.
DR   PaxDb; O75144; -.
DR   PeptideAtlas; O75144; -.
DR   PRIDE; O75144; -.
DR   ProteomicsDB; 2140; -.
DR   ProteomicsDB; 49806; -. [O75144-1]
DR   ProteomicsDB; 49807; -. [O75144-2]
DR   TopDownProteomics; O75144-2; -. [O75144-2]
DR   ABCD; O75144; 8 sequenced antibodies.
DR   Antibodypedia; 24158; 813 antibodies from 44 providers.
DR   CPTC; O75144; 1 antibody.
DR   DNASU; 23308; -.
DR   Ensembl; ENST00000344330.8; ENSP00000339477.4; ENSG00000160223.17. [O75144-2]
DR   Ensembl; ENST00000400377.3; ENSP00000383228.3; ENSG00000160223.17. [O75144-3]
DR   Ensembl; ENST00000407780.7; ENSP00000384432.3; ENSG00000160223.17. [O75144-1]
DR   GeneID; 23308; -.
DR   KEGG; hsa:23308; -.
DR   MANE-Select; ENST00000407780.8; ENSP00000384432.3; NM_015259.6; NP_056074.1.
DR   UCSC; uc002zee.5; human. [O75144-1]
DR   CTD; 23308; -.
DR   DisGeNET; 23308; -.
DR   GeneCards; ICOSLG; -.
DR   HGNC; HGNC:17087; ICOSLG.
DR   HPA; ENSG00000160223; Tissue enhanced (bone marrow, brain).
DR   MIM; 605717; gene.
DR   neXtProt; NX_O75144; -.
DR   OpenTargets; ENSG00000160223; -.
DR   OpenTargets; ENSG00000277117; -.
DR   PharmGKB; PA134977297; -.
DR   VEuPathDB; HostDB:ENSG00000160223; -.
DR   eggNOG; ENOG502SQ2A; Eukaryota.
DR   GeneTree; ENSGT00940000161590; -.
DR   HOGENOM; CLU_013137_8_2_1; -.
DR   InParanoid; O75144; -.
DR   OMA; VYWQIAD; -.
DR   OrthoDB; 1537230at2759; -.
DR   PhylomeDB; O75144; -.
DR   TreeFam; TF331083; -.
DR   PathwayCommons; O75144; -.
DR   Reactome; R-HSA-388841; Costimulation by the CD28 family.
DR   SignaLink; O75144; -.
DR   BioGRID-ORCS; 102723996; 0 hits in 4 CRISPR screens.
DR   BioGRID-ORCS; 23308; 8 hits in 1067 CRISPR screens.
DR   ChiTaRS; ICOSLG; human.
DR   GeneWiki; ICOSLG; -.
DR   Pharos; O75144; Tbio.
DR   PRO; PR:O75144; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; O75144; protein.
DR   Bgee; ENSG00000160223; Expressed in cartilage tissue and 106 other tissues.
DR   ExpressionAtlas; O75144; baseline and differential.
DR   Genevisible; O75144; HS.
DR   GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:HPA.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; NAS:UniProtKB.
DR   GO; GO:0006972; P:hyperosmotic response; NAS:UniProtKB.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; TAS:UniProtKB.
DR   GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; NAS:UniProtKB.
DR   GO; GO:0042110; P:T cell activation; NAS:UniProtKB.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   3D-structure; Adaptive immunity; Alternative splicing; B-cell activation;
KW   Cell membrane; Disulfide bond; Glycoprotein; Immunity;
KW   Immunoglobulin domain; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..302
FT                   /note="ICOS ligand"
FT                   /id="PRO_0000014803"
FT   TOPO_DOM        19..256
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        278..302
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          19..129
FT                   /note="Ig-like V-type"
FT   DOMAIN          141..227
FT                   /note="Ig-like C2-type"
FT   CARBOHYD        70
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:16335952"
FT   CARBOHYD        137
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        173
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        186
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:16335952"
FT   CARBOHYD        225
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        37..113
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        158..216
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   VAR_SEQ         18..134
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_054718"
FT   VAR_SEQ         300..302
FT                   /note="GHV -> ESWNLLLLLS (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:10657606, ECO:0000303|Ref.4"
FT                   /id="VSP_002520"
FT   VARIANT         128
FT                   /note="V -> I (in dbSNP:rs11558819)"
FT                   /id="VAR_049880"
FT   STRAND          20..28
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   STRAND          33..35
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   TURN            47..49
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   STRAND          50..59
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   STRAND          62..66
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   TURN            78..83
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   STRAND          84..86
FT                   /evidence="ECO:0007829|PDB:6X4G"
FT   HELIX           88..92
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   STRAND          98..102
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   HELIX           105..107
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   STRAND          109..117
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   TURN            118..121
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   STRAND          122..136
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   STRAND          142..144
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   STRAND          155..165
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   STRAND          168..173
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   TURN            174..177
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   HELIX           182..184
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   STRAND          185..191
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   HELIX           193..195
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   STRAND          197..204
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   STRAND          213..219
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   TURN            220..223
FT                   /evidence="ECO:0007829|PDB:6X4T"
FT   STRAND          224..229
FT                   /evidence="ECO:0007829|PDB:6X4T"
SQ   SEQUENCE   302 AA;  33349 MW;  647934E21B55E34A CRC64;
     MRLGSPGLLF LLFSSLRADT QEKEVRAMVG SDVELSCACP EGSRFDLNDV YVYWQTSESK
     TVVTYHIPQN SSLENVDSRY RNRALMSPAG MLRGDFSLRL FNVTPQDEQK FHCLVLSQSL
     GFQEVLSVEV TLHVAANFSV PVVSAPHSPS QDELTFTCTS INGYPRPNVY WINKTDNSLL
     DQALQNDTVF LNMRGLYDVV SVLRIARTPS VNIGCCIENV LLQQNLTVGS QTGNDIGERD
     KITENPVSTG EKNAATWSIL AVLCLLVVVA VAIGWVCRDR CLQHSYAGAW AVSPETELTG
     HV
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024