ID   ICOS_BOVIN              Reviewed;         209 AA.
AC   Q58DF9;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Inducible T-cell costimulator;
DE   AltName: CD_antigen=CD278;
DE   Flags: Precursor;
GN   Name=ICOS;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Enhances all basic T-cell responses to a foreign antigen,
CC       namely proliferation, secretion of lymphokines, up-regulation of
CC       molecules that mediate cell-cell interaction, and effective help for
CC       antibody secretion by B-cells. Essential both for efficient interaction
CC       between T and B-cells and for normal antibody responses to T-cell
CC       dependent antigens. Does not up-regulate the production of interleukin-
CC       2, but superinduces the synthesis of interleukin-10. Prevents the
CC       apoptosis of pre-activated T-cells. Plays a critical role in CD40-
CC       mediated class switching of immunoglobin isotypes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; BT021638; AAX46485.1; -; mRNA.
DR   RefSeq; NP_001029447.1; NM_001034275.1.
DR   AlphaFoldDB; Q58DF9; -.
DR   SMR; Q58DF9; -.
DR   STRING; 9913.ENSBTAP00000028775; -.
DR   PaxDb; Q58DF9; -.
DR   PRIDE; Q58DF9; -.
DR   Ensembl; ENSBTAT00000028775; ENSBTAP00000028775; ENSBTAG00000021596.
DR   GeneID; 507026; -.
DR   KEGG; bta:507026; -.
DR   CTD; 29851; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021596; -.
DR   VGNC; VGNC:30030; ICOS.
DR   eggNOG; ENOG502S59F; Eukaryota.
DR   GeneTree; ENSGT00390000000801; -.
DR   HOGENOM; CLU_1315009_0_0_1; -.
DR   InParanoid; Q58DF9; -.
DR   OMA; QDKEDCF; -.
DR   OrthoDB; 1298290at2759; -.
DR   TreeFam; TF335679; -.
DR   Reactome; R-BTA-388841; Costimulation by the CD28 family.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000021596; Expressed in mesenteric lymph node and 66 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR   GO; GO:0031295; P:T cell costimulation; IBA:GO_Central.
DR   GO; GO:0002517; P:T cell tolerance induction; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR039943; ICOS.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR20904; PTHR20904; 1.
DR   Pfam; PF15910; V-set_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..209
FT                   /note="Inducible T-cell costimulator"
FT                   /id="PRO_0000227499"
FT   TOPO_DOM        20..141
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          30..133
FT                   /note="Ig-like V-type"
FT   CARBOHYD        23
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        89
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        42..109
FT                   /evidence="ECO:0000250"
FT   DISULFID        63..83
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   209 AA;  23953 MW;  F288AA99E11B95A6 CRC64;
     MKSDLRYFFL FCIQVEILAG EFNDSAASEM FIFHNGGVQI LCKYPDTVRQ FKMQLLKGDN
     VLCDLTKTKE NEDTVSIRNL NVCKFQLSNN SVSFFLYNLD SSYASYYICK LSIFDPPPFQ
     VDILSREYLN IYESELCCQL KFWLPIGCAA FVTVCVFGCV LMYWLTKKKY PTSVHDPNSE
     YMFMAAVNTA KKPAPTDVTR NLELPGTQA