ID   ICP22_EHV1K             Reviewed;         293 AA.
AC   P68337; P28940;
DT   09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   09-NOV-2004, sequence version 1.
DT   23-FEB-2022, entry version 36.
DE   RecName: Full=Transcriptional regulator ICP22 homolog;
DE   AltName: Full=IR4 protein;
DE   AltName: Full=Immediate-early protein IE68;
DE   AltName: Full=In vitro host-range factor;
DE   AltName: Full=ORF S1-2;
GN   Name=IR4;
OS   Equine herpesvirus 1 (strain Kentucky A) (EHV-1) (Equine abortion virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10329;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1370553; DOI=10.1128/jvi.66.2.664-673.1992;
RA   Holden V.R., Yalamanchili R.R., Harty R.N., O'Callaghan D.J.;
RT   "ICP22 homolog of equine herpesvirus 1: expression from early and late
RT   promoters.";
RL   J. Virol. 66:664-673(1992).
CC   -!- INTERACTION:
CC       P68337; P17473: IE; NbExp=11; IntAct=EBI-11711710, EBI-11702772;
CC       P68337; P68337: IR4; NbExp=5; IntAct=EBI-11711710, EBI-11711710;
CC   -!- SIMILARITY: Belongs to the herpesviridae ICP22 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA46096.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M76726; AAA46092.1; -; Genomic_DNA.
DR   EMBL; M25345; AAA46096.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_053109.1; NC_001491.2.
DR   RefSeq; YP_053123.1; NC_001491.2.
DR   IntAct; P68337; 1.
DR   GeneID; 2948568; -.
DR   GeneID; 2948573; -.
DR   KEGG; vg:2948568; -.
DR   KEGG; vg:2948573; -.
DR   GO; GO:0042025; C:host cell nucleus; IDA:AgBase.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0043621; F:protein self-association; IPI:AgBase.
DR   GO; GO:0010468; P:regulation of gene expression; IMP:AgBase.
DR   InterPro; IPR003403; IE68.
DR   Pfam; PF02479; Herpes_IE68; 1.
PE   1: Evidence at protein level;
KW   Early protein.
FT   CHAIN           1..293
FT                   /note="Transcriptional regulator ICP22 homolog"
FT                   /id="PRO_0000115840"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          175..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..212
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..268
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..283
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   293 AA;  32117 MW;  3D9E89D028276D7F CRC64;
     MPHGQPCGAC DGSCRMAQRG TPSTSPLIPS LTPSPPAGDP SPRSSQRIDA VRVPARLPGG
     SDHPEYGMPL SPRALRPYLA RGPGAFCAPP WRPDVNRLAG DVNRLFRGIS TSSIHVTEDS
     RTLRRALLDF YAMGYTHTRP TLECWQSLLQ LLPEQSFPLR ATLRALNSED RYEQRFLEPP
     SDPPNTLFGE ECDVSGDESP SEEEEEDEAS GESSVSEFSP EEETASSEYD SFSDVGEDDS
     SCTGKWSSSE SESDSESDAP TNNHHPTTRA SAAKKRRKRQ PPKGERPTKS ARR