ID   ICP22_HHV2              Reviewed;         197 AA.
AC   P14379;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   02-JUN-2021, entry version 38.
DE   RecName: Full=Transcriptional regulator ICP22 homolog;
DE   AltName: Full=IE68;
DE   AltName: Full=Immediate-early protein IE4;
DE   Flags: Fragment;
GN   Name=US1;
OS   Human herpesvirus 2 (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10310;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6321634; DOI=10.1099/0022-1317-65-3-451;
RA   Whitton J.L., Clements J.B.;
RT   "The junctions between the repetitive and the short unique sequences of the
RT   herpes simplex virus genome are determined by the polypeptide-coding
RT   regions of two spliced immediate-early mRNAs.";
RL   J. Gen. Virol. 65:451-466(1984).
CC   -!- SIMILARITY: Belongs to the herpesviridae ICP22 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M29384; AAA45848.1; -; Genomic_DNA.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR   InterPro; IPR003403; IE68.
DR   Pfam; PF02479; Herpes_IE68; 1.
PE   3: Inferred from homology;
KW   Early protein.
FT   CHAIN           1..>197
FT                   /note="Transcriptional regulator ICP22 homolog"
FT                   /id="PRO_0000115838"
FT   REGION          1..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          147..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..51
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..76
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         197
SQ   SEQUENCE   197 AA;  21510 MW;  314C23F55C795CBB CRC64;
     MADIPPDPPA LDTTPANHAP PSPLPGSRKR RRPVLPSSSE SEGKPDIESE SSSTESSEDE
     VGDLRGGRRR PPRELGGRYF LDLSAESTTG TESEGTGPSD DDDDDASDGW LVDTPPRKSK
     RPRINLRLTS SPDRRAGVVF PEVWRSDRPI RAAQPQAPAQ SSGDRAHAPR RSARQAQMRS
     GAAWTLDLHY IRQCVNQ