ICP22_VZVO
ID ICP22_VZVO Reviewed; 278 AA.
AC Q77NN7;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 23-FEB-2022, entry version 64.
DE RecName: Full=Transcriptional regulator ICP22 homolog;
DE AltName: Full=Immediate-early protein 63;
DE Short=IE63;
DE AltName: Full=Transcriptional transactivator IE63;
GN ORFNames=ORF63;
GN and
GN ORFNames=ORF70;
OS Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=341980;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=V-Oka(Biken);
RX PubMed=10720545; DOI=10.1086/315335;
RA Argaw T., Cohen J.I., Klutch M., Lekstrom K., Yoshikawa T., Asano Y.,
RA Krause P.R.;
RT "Nucleotide sequences that distinguish Oka vaccine from parental Oka and
RT other varicella-zoster virus isolates.";
RL J. Infect. Dis. 181:1153-1157(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate Human/Japan/P-Oka/1970, and
RC Oka varicella vaccine Biken (V-Oka-Biken);
RX PubMed=12388706; DOI=10.1128/jvi.76.22.11447-11459.2002;
RA Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.;
RT "Comparison of the complete DNA sequences of the Oka varicella vaccine and
RT its parental virus.";
RL J. Virol. 76:11447-11459(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
RC Oka varicella vaccine Varivax V-Oka-Merk);
RX PubMed=18787000; DOI=10.1128/jvi.00777-08;
RA Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
RA Vassilev V.;
RT "Complete DNA sequences of two oka strain varicella-zoster virus genomes.";
RL J. Virol. 82:11023-11044(2008).
CC -!- FUNCTION: Immediate early (EI) protein that functions as a
CC transcriptional regulator of cellular and viral mRNAs mainly by
CC interacting with several general transcription factors thereby
CC disorganizing the preinitiation complex at certain promoters. May
CC additionally help to regulate levels of histones in virus-infected
CC cells by interacting with host ASF1. By inhibiting host transcriptional
CC program, IE63 plays a major role in the ability of VZV to overcome the
CC innate immune response to the virus (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with IE62; this interaction modulates the function
CC of IE62. Interacts with several components of host pre-initiation
CC complex including GTF2E1, GTF2H2 and POLR2A; these interactions lead to
CC repression of gene transcription. Interacts with host ASF1; altering
CC its ability to bind histones.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm. Host nucleus. Virion tegument.
CC Note=During the first stage of infection, IE63 is mostly expressed in
CC the nucleus and also slightly in the cytoplasm, and during latency,
CC IE63 localizes in the cytoplasm quite exclusively.
CC -!- PTM: Phosphorylated in vitro by host and by protein kinase ORF47.
CC -!- SIMILARITY: Belongs to the herpesviridae ICP22 family. {ECO:0000305}.
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DR EMBL; AF206304; AAF61664.1; -; Genomic_DNA.
DR EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DQ008354; AAY57672.1; -; Genomic_DNA.
DR EMBL; DQ008354; AAY57679.1; -; Genomic_DNA.
DR EMBL; DQ008355; AAY57743.1; -; Genomic_DNA.
DR EMBL; DQ008355; AAY57750.1; -; Genomic_DNA.
DR RefSeq; NP_040185.1; NC_001348.1.
DR RefSeq; NP_040192.1; NC_001348.1.
DR BioGRID; 971533; 1.
DR GeneID; 1487700; -.
DR GeneID; 1487711; -.
DR KEGG; vg:1487700; -.
DR KEGG; vg:1487711; -.
DR Proteomes; UP000002603; Genome.
DR Proteomes; UP000008504; Genome.
DR Proteomes; UP000008505; Genome.
DR Proteomes; UP000008506; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR GO; GO:0039523; P:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity; IEA:UniProtKB-KW.
DR InterPro; IPR003403; IE68.
DR Pfam; PF02479; Herpes_IE68; 1.
PE 3: Inferred from homology;
KW Early protein; Eukaryotic host gene expression shutoff by virus;
KW Eukaryotic host transcription shutoff by virus; Host cytoplasm;
KW Host gene expression shutoff by virus; Host nucleus;
KW Host-virus interaction;
KW Inhibition of eukaryotic host transcription initiation by virus;
KW Inhibition of host RNA polymerase II by virus; Transcription;
KW Transcription regulation; Virion; Virion tegument.
FT CHAIN 1..278
FT /note="Transcriptional regulator ICP22 homolog"
FT /id="PRO_0000385459"
FT REGION 1..142
FT /note="IE62-binding"
FT /evidence="ECO:0000250"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..171
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..205
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 278 AA; 30495 MW; 2CFA03C199F9A385 CRC64;
MFCTSPATRG DSSESKPGAS VDVNGKMEYG SAPGPLNGRD TSRGPGAFCT PGWEIHPARL
VEDINRVFLC IAQSSGRVTR DSRRLRRICL DFYLMGRTRQ RPTLACWEEL LQLQPTQTQC
LRATLMEVSH RPPRGEDGFI EAPNVPLHRS ALECDVSDDG GEDDSDDDGS TPSDVIEFRD
SDAESSDGED FIVEEESEES TDSCEPDGVP GDCYRDGDGC NTPSPKRPQR AIERYAGAET
AEYTAAKALT ALGEGGVDWK RRRHEAPRRH DIPPPHGV
