ID   ICP27_GAHVM             Reviewed;         473 AA.
AC   Q77MR3;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=mRNA export factor ICP27 homolog;
DE   AltName: Full=Transcriptional regulator IE63 homolog;
GN   ORFNames=MDV068;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- FUNCTION: Multifunctional regulator of the expression of viral genes
CC       that mediates nuclear export of viral intronless mRNAs. This immediate
CC       early (EI) protein promotes the nuclear export of viral intronless
CC       mRNAs by interacting with mRNAs and host NXF1/TAP (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associates in a complex with RNA, and host export factors
CC       NXF1/TAP and ALYREF; these interactions allow nuclear export of viral
CC       transcripts. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Host nucleus
CC       {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HHV-1 ICP27 protein family. {ECO:0000305}.
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DR   EMBL; AF243438; AAG14248.1; -; Genomic_DNA.
DR   RefSeq; YP_001033984.1; NC_002229.3.
DR   SMR; Q77MR3; -.
DR   PRIDE; Q77MR3; -.
DR   GeneID; 4811529; -.
DR   KEGG; vg:4811529; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR008648; ICP27-like.
DR   Pfam; PF05459; Herpes_UL69; 1.
PE   3: Inferred from homology;
KW   Early protein; Host cytoplasm; Host nucleus; Host-virus interaction;
KW   Metal-binding; Reference proteome; RNA-binding; Zinc; Zinc-finger.
FT   CHAIN           1..473
FT                   /note="mRNA export factor ICP27 homolog"
FT                   /id="PRO_0000406541"
FT   ZN_FING         362..447
FT                   /note="CHC2-type"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   REGION          57..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..81
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         362
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         438
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         442
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         447
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
SQ   SEQUENCE   473 AA;  54499 MW;  2AD9F6CDF0F9F225 CRC64;
     MSVDAFSRES DDMMSLLDYD FIEGSSSDEN AEVTEMETSA KTANNKNEVL FAPPCTQELL
     TERPSPDSKN SQGDDDSNSI YGNVIRDAQH SASRYATRCL DNAIPRKRLR LANLTVDSAC
     ISQTKRPHGT GNRKQYHRRN FPMSPTSQEK IHLRLHNRLG SRSEKQQRSL NYDRRLQEGH
     HRRRFYSERR IYDQNHSHHR THDIRVPLEK YRVSRQHDLP VHEELNEILQ REKHRLASIS
     NECDFRVSSK NRWAAVLTFS SNAESTLCGP QITWEYLLHA GPELRNTFEI RPRISLQASA
     AREAVLRGES FIAALGSAEE TLSWLKLHAV LKLRLVNHDP IFKTAGAVLD NLRLKLAPIM
     MCKYGTEKRS MGDMLRRSAP EDINDSLTLC LILLSRIRRV MHRTSGSKYS YMIDPRGCMI
     DYVPGECMTN ILRYVDAHTR RCSDPACNLY ISCTLMPIYI HGRYFYCNTL FGM