APC11_ARATH
ID APC11_ARATH Reviewed; 84 AA.
AC Q9M9L0; F4J9K5; Q940X6;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 17-FEB-2016, sequence version 3.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Anaphase-promoting complex subunit 11 {ECO:0000303|PubMed:14508008};
DE AltName: Full=Cyclosome subunit 11 {ECO:0000303|PubMed:14508008};
GN Name=APC11 {ECO:0000303|PubMed:14508008};
GN OrderedLocusNames=At3g05870 {ECO:0000312|Araport:AT3G05870};
GN ORFNames=F10A16.17 {ECO:0000312|EMBL:AAF26089.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Okresz L.;
RT "Arabidopsis thaliana anaphase promoting complex subunit 11 mRNA.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX PubMed=26657562; DOI=10.1038/srep18087;
RA Guo L., Liu C.M.;
RT "A single-nucleotide exon found in Arabidopsis.";
RL Sci. Rep. 5:18087-18087(2015).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 28-84.
RC STRAIN=cv. Columbia;
RA Kim C.J., Bautista V.R., Chen H., De Los Reyes C., Wu S.Y., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP INTERACTION WITH APC2.
RX PubMed=14508008; DOI=10.1105/tpc.013847;
RA Capron A., Serralbo O., Fulop K., Frugier F., Parmentier Y., Dong A.,
RA Lecureuil A., Guerche P., Kondorosi E., Scheres B., Genschik P.;
RT "The Arabidopsis anaphase-promoting complex or cyclosome: molecular and
RT genetic characterization of the APC2 subunit.";
RL Plant Cell 15:2370-2382(2003).
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle. The APC/C complex controls several key steps in the cell cycle
CC by mediating ubiquitination and subsequent degradation of target
CC proteins such as cyclins. The APC/C complex is required for the female
CC gametophyte development and is involved in several aspect of
CC development by controlling cell division and cell elongation. Involved
CC in the control of endoreduplication. May recruit the E2 ubiquitin-
CC conjugating enzymes to the complex (By similarity).
CC {ECO:0000250|UniProtKB:Q9NYG5}.
CC -!- PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305}.
CC -!- SUBUNIT: Part of the APC/C complex composed of at least 10 subunits.
CC Interacts with APC2. {ECO:0000269|PubMed:14508008}.
CC -!- INTERACTION:
CC Q9M9L0; Q8H1U5: APC2; NbExp=4; IntAct=EBI-2130744, EBI-1749410;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NYG5}. Nucleus
CC {ECO:0000250|UniProtKB:Q9NYG5}.
CC -!- SIMILARITY: Belongs to the RING-box family. {ECO:0000305}.
CC -!- CAUTION: The sequence shown differs from that proposed in Ref.1 due to
CC the presence of a constitutive single-nucleotide exon.
CC {ECO:0000269|PubMed:26657562}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF26089.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AEE74309.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AEE74310.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY052402; AAL13436.1; -; mRNA.
DR EMBL; AC012393; AAF26089.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE74309.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE74310.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BT030069; ABN04807.1; -; mRNA.
DR RefSeq; NP_001189819.1; NM_001202890.2.
DR RefSeq; NP_001325492.1; NM_001337620.1.
DR RefSeq; NP_187238.2; NM_111461.3.
DR AlphaFoldDB; Q9M9L0; -.
DR SMR; Q9M9L0; -.
DR BioGRID; 5091; 5.
DR IntAct; Q9M9L0; 6.
DR STRING; 3702.AT3G05870.1; -.
DR PaxDb; Q9M9L0; -.
DR PRIDE; Q9M9L0; -.
DR ProteomicsDB; 244451; -.
DR DNASU; 819756; -.
DR GeneID; 819756; -.
DR KEGG; ath:AT3G05870; -.
DR Araport; AT3G05870; -.
DR eggNOG; KOG1493; Eukaryota.
DR HOGENOM; CLU_115512_0_1_1; -.
DR InParanoid; Q9M9L0; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9M9L0; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M9L0; baseline and differential.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd16456; RING-H2_APC11; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR024991; RING-H2_APC11.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF12861; zf-ANAPC11; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cytoplasm; Metal-binding; Mitosis; Nucleus;
KW Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger.
FT CHAIN 1..84
FT /note="Anaphase-promoting complex subunit 11"
FT /id="PRO_0000396847"
FT ZN_FING 34..77
FT /note="RING-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT CONFLICT 7
FT /note="Q -> R (in Ref. 1; AAL13436)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 84 AA; 9738 MW; 06F9856ED95B4E19 CRC64;
MKVKILQWHA VASWTWDAQD ETCGICRMAF DGCCPDCKLP GDDCPLIWGA CNHAFHLHCI
LKWVNSQTSQ AHCPMCRREW QFKE
