ID   ICP27_HHV6U             Reviewed;         515 AA.
AC   P52354;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=mRNA export factor ICP27 homolog;
GN   ORFNames=U42;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- FUNCTION: Immediate early (EI) protein that plays many roles during
CC       productive infection including regulation of viral gene expression and
CC       nuclear export of intronless viral RNAs. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250}. Virion
CC       {ECO:0000250}. Host nucleus. Host cytoplasm. Note=Shuttles between host
CC       nucleus and cytoplasm.
CC   -!- SIMILARITY: Belongs to the HHV-1 ICP27 protein family. {ECO:0000305}.
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DR   EMBL; X83413; CAA58376.1; -; Genomic_DNA.
DR   EMBL; X92436; CAA63168.1; -; Genomic_DNA.
DR   RefSeq; NP_042935.1; NC_001664.2.
DR   SMR; P52354; -.
DR   PRIDE; P52354; -.
DR   GeneID; 1487920; -.
DR   KEGG; vg:1487920; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR008648; ICP27-like.
DR   Pfam; PF05459; Herpes_UL69; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Metal-binding; Reference proteome;
KW   Transcription; Transcription regulation; Virion; Virion tegument; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..515
FT                   /note="mRNA export factor ICP27 homolog"
FT                   /id="PRO_0000115828"
FT   ZN_FING         230..342
FT                   /note="CHC2-type"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   REGION          398..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         230
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         335
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         337
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         342
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   CONFLICT        50..52
FT                   /note="QLD -> HC (in Ref. 1; CAA58376)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   515 AA;  59886 MW;  22AE3A86D6C43491 CRC64;
     MYPRGVKRSH HDYHRQTAFR TIKRSTHRQT SKFISHFAKN FRGKLAPLKQ LDESRLDALS
     LTELEQLKTI IEEKQQEKRA QNNAITFLPN LPTVPFADTN FSLKSLGLRP YNGDARDPKQ
     RIRDRFPQTH ERICLLTNDI LETDLLLRYR QCLDSLTREE NQQLMGDRIF SLTNSPCLAF
     TVATVEEACS YFKFHDLHNL PVNPQDLFMY TITVMKFEFF NKLNMAKLTC VFNDNGHGDI
     EYRKLRQLCG KPVLDREMPN SELEVQQQTP DSFRHPIQQA MSIVVTFARI LRQIKEQIIQ
     TKKPQFIRDF DTGRVAERYE CGLMSRLIGK QFSNHKCDDV SCQNRIERIM APWKPSLFFC
     TYFAKDAPKF KLFPNFPEEY RNLSFTCPKV DTEPSCSYST NHDLPQTSHR SHKNHGTPKV
     KSKVCVEKPD TSILTTTKTT TEILIEESME TDNKIPNPRE LNFNQAKQEE IVIININENV
     NSKHESESSV EMDLDLDYEA DTCETNLNAC SSDSE