ID   ICP27_HHV6Z             Reviewed;         516 AA.
AC   P52539;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=mRNA export factor ICP27 homolog;
GN   ORFNames=KA3L, U42;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7983761; DOI=10.1128/jvi.69.1.589-596.1995;
RA   Stamey F.R., Dominguez G., Black J.B., Dambaugh T.R., Pellett P.E.;
RT   "Intragenomic linear amplification of human herpesvirus 6B oriLyt suggests
RT   acquisition of oriLyt by transposition.";
RL   J. Virol. 69:589-596(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
CC   -!- FUNCTION: Immediate early (EI) protein that plays many roles during
CC       productive infection including regulation of viral gene expression and
CC       nuclear export of intronless viral RNAs. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250}. Virion
CC       {ECO:0000250}. Host nucleus. Host cytoplasm. Note=Shuttles between host
CC       nucleus and cytoplasm.
CC   -!- SIMILARITY: Belongs to the HHV-1 ICP27 protein family. {ECO:0000305}.
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DR   EMBL; AF157706; AAB06340.1; -; Genomic_DNA.
DR   PIR; T44002; T44002.
DR   RefSeq; NP_050223.1; NC_000898.1.
DR   PRIDE; P52539; -.
DR   DNASU; 1497044; -.
DR   GeneID; 1497044; -.
DR   KEGG; vg:1497044; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR008648; ICP27-like.
DR   Pfam; PF05459; Herpes_UL69; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Metal-binding; Reference proteome;
KW   Transcription; Transcription regulation; Virion; Virion tegument; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..516
FT                   /note="mRNA export factor ICP27 homolog"
FT                   /id="PRO_0000115829"
FT   ZN_FING         231..343
FT                   /note="CHC2-type"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   REGION          399..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        399..414
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         231
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         336
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         338
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         343
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
SQ   SEQUENCE   516 AA;  60114 MW;  6DCE98D04827BFDB CRC64;
     MYPRGVKRSQ HDRHKQTAFR TIKRSITHRP TSKFISHFAK NFRGKLAPLK QLDESRLDAL
     SLTELEQLKT IIEEKQQEKR AQNNAITFLP NLPTVPFADT NFSIKSLGLR PYNGDARDPK
     QRIRDRFPQT HERICLLTND ILETDLLLRY RQCLDSLTRE ENQQLMGDRI FSLTNSPCLA
     FTVATVEEAC SYFKFHDLHN LPVNPQDLFM YTITVMKFEF FNKLNMAKLT CVFNDNGHGD
     IEYRKLRQLC GKPVLDREMP NSEFEVQQQT PDSFRHPIQQ AMSIVVTFAR ILRQIKEHII
     RTKKPQFIRD FDTERVAERY ECGLISRLIG KQFSNHKCDD VSCQNRIERI MAPWKPSLFF
     CTYFAKDAPK FKLFPNLPHE YRNLSFTCPK VDMEPSCSYS TSRDLPQTSH RSHKNQGTPK
     VKSKVCVEKP DTSNLTTTKT TTEILIEESM ETDNKIPDPR ELNFNQAKQD EIVIININEN
     VNSKHESESS VEMDLDLDYE ADTCETNLNT YSSDSE