ID   ICP27_HHV7J             Reviewed;         526 AA.
AC   P52355;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=mRNA export factor ICP27 homolog;
GN   ORFNames=U42;
OS   Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=57278;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8709220; DOI=10.1128/jvi.70.9.5975-5989.1996;
RA   Nicholas J.;
RT   "Determination and analysis of the complete nucleotide sequence of human
RT   herpesvirus.";
RL   J. Virol. 70:5975-5989(1996).
CC   -!- FUNCTION: Immediate early (EI) protein that plays many roles during
CC       productive infection including regulation of viral gene expression and
CC       nuclear export of intronless viral RNAs. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250}. Virion
CC       {ECO:0000250}. Host nucleus. Host cytoplasm. Note=Shuttles between host
CC       nucleus and cytoplasm.
CC   -!- SIMILARITY: Belongs to the HHV-1 ICP27 protein family. {ECO:0000305}.
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DR   EMBL; U43400; AAC54704.1; -; Genomic_DNA.
DR   PIR; T41944; T41944.
DR   Proteomes; UP000009246; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR008648; ICP27-like.
DR   Pfam; PF05459; Herpes_UL69; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Metal-binding; Reference proteome;
KW   Transcription; Transcription regulation; Virion; Virion tegument; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..526
FT                   /note="mRNA export factor ICP27 homolog"
FT                   /id="PRO_0000115830"
FT   ZN_FING         239..351
FT                   /note="CHC2-type"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         239
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         344
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         346
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         351
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
SQ   SEQUENCE   526 AA;  61754 MW;  693C4B33FCD34A24 CRC64;
     MNKVLIFDRN MYPRGVKKNV LGRQRYGLKT IKRTLVHKPA NKYVSRFTKQ FHRRIIPIKQ
     LDESKLDALS LRELEQLKLI IEEKQEEKRA QTHALTFFAN LPTAPFGSSY TAEALGLRKY
     SGEARDPAHR IRDRFPRNHE KIYLEKEELM TTDLLLRYKN CLNSLNREQH QQILGDRVFS
     LTNSPSLAFS LAIIEEACIY YKYHFVHNLP IDPQDLFMYT ITIMKFEYFN KLNMAKLCCV
     FNDNGHGDIE YRIFRQLCGK PVYDRDMPNT EYEVQQQTPG SFQYPAQQAL SFIVTFARIL
     RQIKERILQT KQPQFIRDFD QDRVSEQYQC GMISRLVGDQ FNNHQCDDIG CQTRIQRMMS
     PWKPSLYFCT YLPKEFVEFG LHPNMPEEYN SFNVACSTTP SCSFASQQSK QTVQLNLQTK
     KQAKCKKLLT ADKTNKGQKT NELRENRLKK DWSKEVDSID FETNTTLQED ETRFVFIEND
     TSMKSAKIKE NNGEENSDNE MELDLDYEDV ETCETDINDT DSDDSD