ICP27_MUHVS
ID ICP27_MUHVS Reviewed; 841 AA.
AC Q69154;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=mRNA export factor ICP27 homolog;
GN ORFNames=UL69;
OS Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Muromegalovirus.
OX NCBI_TaxID=10367;
OH NCBI_TaxID=10090; Mus musculus (Mouse).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7483291; DOI=10.1007/bf01724298;
RA Messerle M., Rapp M., Lucin P., Koszinowski U.H.;
RT "Characterization of a conserved gene block in the murine cytomegalovirus
RT genome.";
RL Virus Genes 10:73-80(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=8971012; DOI=10.1128/jvi.70.12.8833-8849.1996;
RA Rawlinson W.D., Farrell H.E., Barrell B.G.;
RT "Analysis of the complete DNA sequence of murine cytomegalovirus.";
RL J. Virol. 70:8833-8849(1996).
CC -!- FUNCTION: Immediate early (EI) protein that plays many roles during
CC productive infection including regulation of viral gene expression and
CC nuclear export of intronless viral RNAs. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250}. Virion
CC {ECO:0000250}. Host nucleus. Host cytoplasm. Note=Shuttles between host
CC nucleus and cytoplasm.
CC -!- SIMILARITY: Belongs to the HHV-1 ICP27 protein family. {ECO:0000305}.
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DR EMBL; L07319; AAA96666.1; -; Genomic_DNA.
DR EMBL; U68299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PRIDE; Q69154; -.
DR Proteomes; UP000008774; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR008648; ICP27-like.
DR Pfam; PF05459; Herpes_UL69; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host nucleus; Metal-binding; Reference proteome;
KW Transcription; Transcription regulation; Virion; Virion tegument; Zinc;
KW Zinc-finger.
FT CHAIN 1..841
FT /note="mRNA export factor ICP27 homolog"
FT /id="PRO_0000115836"
FT ZN_FING 298..418
FT /note="CHC2-type"
FT /evidence="ECO:0000250|UniProtKB:P10238"
FT REGION 12..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..514
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..669
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..727
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..749
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..806
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 298
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P10238"
FT BINDING 411
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P10238"
FT BINDING 413
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P10238"
FT BINDING 418
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P10238"
SQ SEQUENCE 841 AA; 92707 MW; 9F18372739D723E4 CRC64;
MLRTGVKRRL GPFAGYDEDD AATGGVSRRS KYSQQQSQHY YYGHNQSSYR DSGASHPNWK
RNAHLMPPPL SSPSSPPPQY DKNIAALTHL NKKLDCLGPD DLECLKAMIR IREARAQGRR
PEPSSAPSIL ESSLVSSNNS NNNTTLSLGG GGGGDYHRQT SPDIRDYTTG SLGLCMFPMD
LPDPIKLLEN RYTDNDRHAP AVVTHDELIN TNYLLLFRKH FDALPPEELR VLVQDRTFAI
NNAPSLDVVA AMADENLTYV KFHRVHNLPV NPKDLYMSTL GLIKYATFNK LNLGELSCLL
DSPGGGGSDR EYHILRQIAN KPASPCRKGG SSAAAAASFD VLRRPPLSFK HPLQQALALI
ASFARIVGVI RRRSLRHSGP FFIRDFDDTG ATDSYRCGMI SELIFDYLPG HRCQNEICRV
KLKKLLQPYT STLFFCAYNN TRKHPNGLPA RRSPERRAPD ATPNIPRLAY RRSATTSPEV
EPAPPSRMTS SSPRVDSRGG GGDRRGDSSS TSSNHHRHHT RRARTRSTHD SSSSGSRRRS
SATDGRRSRR GSRRGEAQRE SNGHHSSKSP STVSSTTVHG QNGARGDSAP SRKSQQSQQQ
PETTSKESSK TAAMPPPPSP CSPSPASRER RPSKSPSSSP RPHDPPSGEP ADAEKELATA
GDEDEGVRSP GECSVATRRG SSADESSDSS SSSSDSSSSS DEEESDVEDC RELDLQSKRL
EEALEERCER DFEADDEEFA EPIEEDDLHC SLDMEEDIED EPLDPETESV WTASVTPLAA
PPSIRILDHE PGDAEEEEES DTDFYDETDQ PLNKRIHLRS ATPTDDVIME CDLSYSEMDS
D
