ID   ICP27_PSHV1             Reviewed;         639 AA.
AC   Q6UDM4;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=mRNA export factor;
DE   AltName: Full=Immediate-early protein IE63;
DE   AltName: Full=Infected cell protein 27;
DE            Short=ICP27;
GN   ORFNames=UL54;
OS   Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1)
OS   (Pacheco's disease virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Iltovirus.
OX   NCBI_TaxID=670426;
OH   NCBI_TaxID=152276; Amazona oratrix (yellow-headed parrot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16873243; DOI=10.1128/jvi.00134-06;
RA   Thureen D.R., Keeler C.L. Jr.;
RT   "Psittacid herpesvirus 1 and infectious laryngotracheitis virus:
RT   Comparative genome sequence analysis of two avian alphaherpesviruses.";
RL   J. Virol. 80:7863-7872(2006).
CC   -!- FUNCTION: Multifunctional regulator of the expression of viral genes
CC       that mediates nuclear export of viral intronless mRNAs. This immediate
CC       early (EI) protein promotes the nuclear export of viral intronless
CC       mRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Host nucleus
CC       {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HHV-1 ICP27 protein family. {ECO:0000305}.
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DR   EMBL; AY372243; AAQ73686.1; -; Genomic_DNA.
DR   RefSeq; NP_944380.1; NC_005264.1.
DR   SMR; Q6UDM4; -.
DR   PRIDE; Q6UDM4; -.
DR   GeneID; 2657008; -.
DR   KEGG; vg:2657008; -.
DR   Proteomes; UP000006840; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR008648; ICP27-like.
DR   Pfam; PF05459; Herpes_UL69; 1.
PE   3: Inferred from homology;
KW   Early protein; Host cytoplasm; Host nucleus; Host-virus interaction;
KW   Metal-binding; Reference proteome; RNA-binding; Zinc; Zinc-finger.
FT   CHAIN           1..639
FT                   /note="mRNA export factor"
FT                   /id="PRO_0000406858"
FT   ZN_FING         525..615
FT                   /note="CHC2-type"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          63..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..143
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..189
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..226
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        234..266
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..355
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         525
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         606
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         610
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
FT   BINDING         615
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:P10238"
SQ   SEQUENCE   639 AA;  71523 MW;  C9D59D7A13B737F8 CRC64;
     MQAEQTRCAA ARGSAEMESL WHAAPGDEEI PLHPPPTPGA MSLESDSSLD TLAEKIECDL
     MDLLGDMGPP CDIDEEEDQL FAEALPPLYS QPTENPPPPN AANSIPEQAG KQPAEGKTNT
     ERNERPMRRK RREDGDVGQP NPRRRTHARS RSPRAGSTSS QQPPSSSGGA RKPCVRREAG
     DRETSEKPAR GKYCAPFPRQ APHQCQSPPA QTASQKPPPR PQRPPSTTAY SPDRTPHDHQ
     ERRHEGAGKM IRSVVTKQDA RKPPRRVPHR GCGTGRHGRR TPEKWGAPPS MVVPLKFTRE
     YWEKHRNELK KPVWRDYSRS ACTARDPARA HDSGAECPPT EKRDERRTCA PSQPRWLRED
     RNAARFFDKA KDAFGGLALP TDDMCTRNRD LLRAMADEVV DDDDCEDLDL TRQMCFPTMI
     GPQSRAAGPV GARMDSWSEL CRRAAFLKAR WSSQPSVTRV ARAVRSLYLT NCSFDELLEA
     CDETLTWMLW HQFEDERLCP HDPIFSNIYA LVQGLVTRLG AVLHCHLAAS KSPLADPTRT
     SELPLQSATC PLTLFLTFAD RFARVMHGHP HVTLVGHKIV DHEGVLRTLY LPGMCARKIP
     VVLDQHANVC RKEECRLLCA QLLGKQYTVG KFLCCDLYA