ID   ICP2_ENTHI              Reviewed;         123 AA.
AC   Q4GZL2;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Amoebiasin-2;
DE   AltName: Full=Cysteine protease inhibitor 2;
DE   AltName: Full=EhICP2;
DE            Short=ICP-2;
DE   Flags: Precursor;
GN   Name=ICP2;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, AND
RP   SUBCELLULAR LOCATION.
RC   STRAIN=ATCC 30459 / HM-1:IMSS;
RX   PubMed=16802137; DOI=10.1007/s00436-006-0206-z;
RA   Saric M., Vahrmann A., Bruchhaus I., Bakker-Grunwald T., Scholze H.;
RT   "The second cysteine protease inhibitor, EhICP2, has a different
RT   localization in trophozoites of Entamoeba histolytica than EhICP1.";
RL   Parasitol. Res. 100:171-174(2006).
CC   -!- FUNCTION: Inhibits soluble trophozoite extract.
CC       {ECO:0000269|PubMed:16802137}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle
CC       {ECO:0000269|PubMed:16802137}.
CC   -!- TISSUE SPECIFICITY: Expressed in trophozoites (at protein level).
CC       {ECO:0000269|PubMed:16802137}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I42 family.
CC       {ECO:0000305}.
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DR   EMBL; AJ890473; CAI77274.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4GZL2; -.
DR   SMR; Q4GZL2; -.
DR   MEROPS; I42.003; -.
DR   VEuPathDB; AmoebaDB:EHI5A_123780; -.
DR   VEuPathDB; AmoebaDB:EHI7A_091380; -.
DR   VEuPathDB; AmoebaDB:EHI8A_094330; -.
DR   VEuPathDB; AmoebaDB:EHI_040460; -.
DR   VEuPathDB; AmoebaDB:KM1_163750; -.
DR   eggNOG; ENOG502RH63; Eukaryota.
DR   OMA; TGYAWNI; -.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.2020; -; 1.
DR   InterPro; IPR036331; Chagasin-like_sf.
DR   InterPro; IPR018990; Prot_inh_I42_chagasin.
DR   Pfam; PF09394; Inhibitor_I42; 1.
DR   SUPFAM; SSF141066; SSF141066; 1.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Protease inhibitor; Signal; Thiol protease inhibitor.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..123
FT                   /note="Amoebiasin-2"
FT                   /id="PRO_5000074670"
SQ   SEQUENCE   123 AA;  14000 MW;  7B7A469353F73B68 CRC64;
     MKQFIFFALL CTSTYAAIHI LTEKEDHATL HISFNDLIKI QLRTNPSTGY AWNIEYPTDT
     FSLSQDTIKA EPHPSGMVGF PSIREIQLKP LKVGTTTIKL GYSRPWEKGK EPLRSLTYSV
     VIR