ID   ICP47_CHV1E             Reviewed;          81 AA.
AC   Q8JP02; Q8V717;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   23-FEB-2022, entry version 56.
DE   RecName: Full=ICP47 protein;
DE   AltName: Full=Immediate-early protein IE12;
DE   AltName: Full=Immediate-early-5;
DE   AltName: Full=Infected cell protein 47;
DE   AltName: Full=US12 protein;
DE   AltName: Full=Vmw12;
GN   Name=US12;
OS   Cercopithecine herpesvirus 1 (strain E2490) (CeHV-1) (Simian herpes B
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=260965;
OH   NCBI_TaxID=9541; Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OH   NCBI_TaxID=9544; Macaca mulatta (Rhesus macaque).
OH   NCBI_TaxID=9545; Macaca nemestrina (Pig-tailed macaque).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Bigger J.E., Martin D.W.;
RT   "Comparison of ICP47 homologs from the primate simplexviruses.";
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   COMPLETE GENOME.
RX   PubMed=12743273; DOI=10.1128/jvi.77.11.6167-6177.2003;
RA   Perelygina L., Zhu L., Zurkuhlen H., Mills R., Borodovsky M.,
RA   Hilliard J.K.;
RT   "Complete sequence and comparative analysis of the genome of herpes B virus
RT   (Cercopithecine herpesvirus 1) from a rhesus monkey.";
RL   J. Virol. 77:6167-6177(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 4-81.
RX   PubMed=11773425; DOI=10.1128/jvi.76.3.1516-1520.2002;
RA   Ohsawa K., Black D.H., Sato H., Eberle R.;
RT   "Sequence and genetic arrangement of the U(S) region of the monkey B virus
RT   (cercopithecine herpesvirus 1) genome and comparison with the U(S) regions
RT   of other primate herpesviruses.";
RL   J. Virol. 76:1516-1520(2002).
CC   -!- FUNCTION: Plays a role in the inhibition of host immune response. Binds
CC       specifically to transporters associated with antigen processing (TAP),
CC       thereby blocking peptide-binding and translocation by TAP as well as
CC       subsequent loading of peptides onto MHC class I molecules. Empty MHC I
CC       molecules are retained in the endoplasmic reticulum and ultimately
CC       directed to proteasomal degradation. In consequence, infected cells are
CC       masked for immune recognition by cytotoxic T-lymphocytes.
CC       {ECO:0000250|UniProtKB:P03170}.
CC   -!- SUBUNIT: Interacts with host TAP1 and TAP2; these interactions inhibit
CC       the loading of peptides onto MHC class I molecules.
CC       {ECO:0000250|UniProtKB:P03170}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:P03170}.
CC       Host nucleus {ECO:0000250|UniProtKB:P03170}.
CC   -!- DOMAIN: The N-terminal active domain blocks peptide binding to and
CC       peptide transport by TAP. {ECO:0000250|UniProtKB:P14345}.
CC   -!- SIMILARITY: Belongs to the herpesviridae US12 family. {ECO:0000305}.
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DR   EMBL; AF533542; AAM97357.1; -; Genomic_DNA.
DR   EMBL; AF533768; AAP41490.1; -; Genomic_DNA.
DR   EMBL; AB074432; BAB83760.1; -; Genomic_DNA.
DR   RefSeq; NP_851932.1; NC_004812.1.
DR   SMR; Q8JP02; -.
DR   GeneID; 1487466; -.
DR   KEGG; vg:1487466; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039588; P:suppression by virus of host antigen processing and presentation; IEA:UniProtKB-KW.
DR   InterPro; IPR008026; Herpes_ICP47.
DR   Pfam; PF05363; Herpes_US12; 1.
PE   3: Inferred from homology;
KW   Early protein; Host cytoplasm; Host nucleus; Host-virus interaction;
KW   Inhibition of host adaptive immune response by virus;
KW   Inhibition of host TAP by virus; Viral immunoevasion.
FT   CHAIN           1..81
FT                   /note="ICP47 protein"
FT                   /id="PRO_0000115812"
FT   REGION          3..36
FT                   /note="Active domain"
FT                   /evidence="ECO:0000250|UniProtKB:P14345"
FT   REGION          37..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        4..7
FT                   /note="RYLA -> GTWS (in Ref. 3; BAB83760)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   81 AA;  8946 MW;  CBD78EB9C31100D1 CRC64;
     MSSRYLAAVD DYLHHPSPRY QAHVDLRREL RAYADEERRE AARAIAHPER PLLPPPATQA
     APPQPSTREA AHPSAPTAAS S