ID   ICP47_HSV2S             Reviewed;          78 AA.
AC   P60504;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 1.
DT   23-FEB-2022, entry version 48.
DE   RecName: Full=ICP47 protein;
DE   AltName: Full=Immediate-early protein IE12;
DE   AltName: Full=Immediate-early-5;
DE   AltName: Full=Infected cell protein 47;
DE   AltName: Full=US12 protein;
DE   AltName: Full=Vmw12;
GN   Name=US12;
OS   Herpes simplex virus type 2 (strain SA8) (Simian agent 8).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10316;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate B264;
RA   Bigger J.E., Martin D.W.;
RT   "Identification of an ICP47 homolog in Simian agent 8 (SA8).";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the inhibition of host immune response. Binds
CC       specifically to transporters associated with antigen processing (TAP),
CC       thereby blocking peptide-binding and translocation by TAP as well as
CC       subsequent loading of peptides onto MHC class I molecules. Empty MHC I
CC       molecules are retained in the endoplasmic reticulum and ultimately
CC       directed to proteasomal degradation. In consequence, infected cells are
CC       masked for immune recognition by cytotoxic T-lymphocytes.
CC       {ECO:0000250|UniProtKB:P03170}.
CC   -!- SUBUNIT: Interacts with host TAP1 and TAP2; these interactions inhibit
CC       the loading of peptides onto MHC class I molecules.
CC       {ECO:0000250|UniProtKB:P03170}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:P03170}.
CC       Host nucleus {ECO:0000250|UniProtKB:P03170}.
CC   -!- DOMAIN: The N-terminal active domain blocks peptide binding to and
CC       peptide transport by TAP. {ECO:0000250|UniProtKB:P14345}.
CC   -!- SIMILARITY: Belongs to the herpesviridae US12 family. {ECO:0000305}.
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DR   EMBL; AY387672; AAQ90018.1; -; Genomic_DNA.
DR   SMR; P60504; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039588; P:suppression by virus of host antigen processing and presentation; IEA:UniProtKB-KW.
DR   InterPro; IPR008026; Herpes_ICP47.
DR   Pfam; PF05363; Herpes_US12; 1.
PE   3: Inferred from homology;
KW   Early protein; Host cytoplasm; Host nucleus; Host-virus interaction;
KW   Inhibition of host adaptive immune response by virus;
KW   Inhibition of host TAP by virus; Viral immunoevasion.
FT   CHAIN           1..78
FT                   /note="ICP47 protein"
FT                   /id="PRO_0000115814"
FT   REGION          3..36
FT                   /note="Active domain"
FT                   /evidence="ECO:0000250|UniProtKB:P14345"
FT   REGION          39..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   78 AA;  8572 MW;  2A3942EF70406125 CRC64;
     MSSLYLATVD AFLRNPHTRH RTCADLRREL DAYADEERRE AAKAIAHPDR PLLAPPSAPP
     NHSHLAARET APPPAATP