ID   ICP4_EHV1B              Reviewed;        1487 AA.
AC   P28925; Q6DLD1;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   02-JUN-2021, entry version 94.
DE   RecName: Full=Major viral transcription factor;
DE   AltName: Full=155 kDa immediate-early protein;
GN   Name=IE; OrderedLocusNames=64;
OS   Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=31520;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1318606; DOI=10.1016/0042-6822(92)90706-u;
RA   Telford E.A.R., Watson M.S., McBride K., Davison A.J.;
RT   "The DNA sequence of equine herpesvirus-1.";
RL   Virology 189:304-316(1992).
CC   -!- FUNCTION: This IE protein is a multifunctional protein capable of
CC       migrating to the nucleus, binding to DNA, trans-activating other viral
CC       genes, and autoregulating its own synthesis.
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- PTM: A long stretch of serine residues may be a major site of
CC       phosphorylation.
CC   -!- SIMILARITY: Belongs to the herpesviridae ICP4 family. {ECO:0000305}.
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DR   EMBL; AY665713; AAT67337.1; -; Genomic_DNA.
DR   EMBL; AY665713; AAT67321.1; -; Genomic_DNA.
DR   PIR; A36802; EDBEF6.
DR   RefSeq; YP_053108.1; NC_001491.2.
DR   RefSeq; YP_053124.1; NC_001491.2.
DR   SMR; P28925; -.
DR   GeneID; 2948555; -.
DR   GeneID; 2948574; -.
DR   KEGG; vg:2948555; -.
DR   KEGG; vg:2948574; -.
DR   Proteomes; UP000001189; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039695; P:DNA-templated viral transcription; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005205; Herpes_ICP4_C.
DR   InterPro; IPR005206; Herpes_ICP4_N.
DR   Pfam; PF03585; Herpes_ICP4_C; 1.
DR   Pfam; PF03584; Herpes_ICP4_N; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Early protein; Host nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..1487
FT                   /note="Major viral transcription factor"
FT                   /id="PRO_0000115816"
FT   REGION          41..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          310..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          803..1007
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        275..289
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..369
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        803..819
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        843..912
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        917..933
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        990..1004
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1487 AA;  154869 MW;  1D4397838D03680D CRC64;
     MASQRSDFAP DLYDFIESND FGEDPLIRAA SAAEEGFTQP AAPDLLYGSQ NMFGVDDAPL
     STPAVVIPPP SPTPEPRGGK AKRSPSAAGS GGPPTPAAAA QPASPAPSPA PGLAAMLKMV
     HSSVAPGNGR RATGSSSPGG GDAADPVALD SDTETCPGSP QPEFPSSASP GGGSPAPRVR
     SISISSSSSS SSSMDEDDQA DGAGASSSSS SSSDDSDSDE GGEEETPRPR HSQNAAKTPS
     AAGSPGPSSG GDRPAAGAAT PKSCRSGAAS PGAPAPAPAS APAPSRPGGG LLPPGARILE
     YLEGVREANL AKTLERPEPP AGMASPPGRS PHRLPKDQRP KSALAGASKR KRANPRPIPQ
     TQTQAPAEEA PQTAVWDLLD MNSSQATGAA AAAASAPAAA SCAPGVYQRE PLLTPSGDPW
     PGSDPPPMGR VRYGGTGDSR DGLWDDPEIV LAASRYAEAQ APVPVFVPEM GDSTKQYNAL
     VRMVFESREA MSWLQNSKLS GQDQNLAQFC QKFIHAPRGH GSFITGSVAN PLPHIGDAMA
     AGNALWALPH AAASVAMSRR YDRTQKSFIL QSLRRAYADM AYPRDEAGRP DSLAAVAGYP
     AQAAAAAASQ QQPEAPAPSV RVREAYTRVC AALGPRRKAA AAAAAPGTRA PRPSAFRLRE
     LGDACVLACQ AVFEALLRLR GGASAVPGLD PSEIPSPACP PEALCSNPAG LETAALSLYE
     LRDLVERARL LGDSDPTHRL GSDELRLAVR AVLVVARTVA PLVRYNAEGA RARASAWTVT
     QAVFSIPSLV GGMLGEAVSL LAPPTRSQQP SSSSPGGEPF SGSAAAEGSL QTLPPLWPTV
     PGKQSATVPS SHSQSPQHSQ SGGGAGATTA TCCRATQTNA RSRGQQHQPQ KARSPQAAAS
     PAHLSQEAMP GSSSDDRAIH GRPRGKSGKR RSEPLEPAAQ AGASASFSSS ARGYDPSGPV
     DSPPAPKRRV ATPGHQAPRA LGPMPAEGPD RRGGFRRVPR GDCHTPRPSD AACAAYCPPE
     LVAELIDNQL FPEAWRPALT FDPQALATIA ARCSGPPARD GARFGELAAS GPLRRRAAWM
     HQIPDPEDVK VVVLYSPLQD EDLLGGLPAS RPGGSRREPL WSDLKGGLSA LLAALGNRIL
     TKRSHAWAGN WTGAPDVSAL NAQGVLLLST GDLAFTGCVE YLCLRLGSAR RKLLVLDAVS
     TEDWPQDGPA ISQYHIYMRA ALTPRVACAV RWPRERHLSR AVLTSSTLFG PGLFARAEAA
     FARLYPDSAP LRLCRSSNVA YTVDTRAGER TRVPLAPREY RQRVLPDYDG CKDMRAQAEG
     LGFHDPDFEE GAAQSHRAAN RWGLGAWLRP VYLACGRRGA GAVEPSELLI PELLSEFCRV
     ALLEPDAEAE PLVLPITEAP RRRAPRVDWE PGFGSRSTSV LHMGATELCL PEPDDELEID
     GAGDVELVVE HPGPSPGVAQ ALRRAPIKIE VVSDDEDGGD WCNPYLS