ICP4_EHV1K
ID ICP4_EHV1K Reviewed; 1487 AA.
AC P17473;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 02-JUN-2021, entry version 81.
DE RecName: Full=Major viral transcription factor;
DE AltName: Full=155 kDa immediate-early protein;
GN Name=IE;
OS Equine herpesvirus 1 (strain Kentucky A) (EHV-1) (Equine abortion virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=10329;
OH NCBI_TaxID=9796; Equus caballus (Horse).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2549711; DOI=10.1016/0042-6822(89)90124-4;
RA Grundy F.J., Baumann R.P., O'Callaghan D.J.;
RT "DNA sequence and comparative analyses of the equine herpesvirus type 1
RT immediate early gene.";
RL Virology 172:223-236(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1432-1487.
RX PubMed=2555546; DOI=10.1128/jvi.63.12.5101-5110.1989;
RA Harty R.N., Colle C.F. III, Grundy F.J., O'Callaghan D.J.;
RT "Mapping the termini and intron of the spliced immediate-early transcript
RT of equine herpesvirus 1.";
RL J. Virol. 63:5101-5110(1989).
CC -!- FUNCTION: This IE protein is a multifunctional protein capable of
CC migrating to the nucleus, binding to DNA, trans-activating other viral
CC genes, and autoregulating its own synthesis.
CC -!- INTERACTION:
CC P17473; P68337: IR4; NbExp=11; IntAct=EBI-11702772, EBI-11711710;
CC P17473; Q00403: GTF2B; Xeno; NbExp=4; IntAct=EBI-11702772, EBI-389564;
CC P17473; P87662: ICP0; Xeno; NbExp=3; IntAct=EBI-11702772, EBI-11712595;
CC P17473; P35268: RPL22; Xeno; NbExp=2; IntAct=EBI-11702772, EBI-354533;
CC P17473; P20226-1: TBP; Xeno; NbExp=2; IntAct=EBI-11702772, EBI-12516310;
CC -!- SUBCELLULAR LOCATION: Host nucleus.
CC -!- PTM: A long stretch of serine residues may be a major site of
CC phosphorylation.
CC -!- SIMILARITY: Belongs to the herpesviridae ICP4 family. {ECO:0000305}.
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DR EMBL; J04366; AAA46089.1; -; Genomic_DNA.
DR EMBL; M30498; AAA66554.1; -; Genomic_DNA.
DR PIR; A33764; EDBEE1.
DR SMR; P17473; -.
DR IntAct; P17473; 6.
DR GO; GO:0044095; C:host cell nucleoplasm; IDA:AgBase.
DR GO; GO:0042025; C:host cell nucleus; IDA:AgBase.
DR GO; GO:0003677; F:DNA binding; IDA:AgBase.
DR GO; GO:0039695; P:DNA-templated viral transcription; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:AgBase.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0050434; P:positive regulation of viral transcription; IMP:AgBase.
DR InterPro; IPR005205; Herpes_ICP4_C.
DR InterPro; IPR005206; Herpes_ICP4_N.
DR Pfam; PF03585; Herpes_ICP4_C; 1.
DR Pfam; PF03584; Herpes_ICP4_N; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Early protein; Host nucleus; Phosphoprotein; Transcription;
KW Transcription regulation.
FT CHAIN 1..1487
FT /note="Major viral transcription factor"
FT /id="PRO_0000115817"
FT REGION 41..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..289
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..912
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..933
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1487 AA; 154717 MW; 044E39A570608A6B CRC64;
MASQRSDFAP DLYDFIESND FGEDPLIRAA SAAEEGFTQP AAPDLLYGSQ NMFGVDDAPL
STPVVVIPPP SPAPEPRGGK AKRSPSAAGS GGPPTPAAAA QPASPAPSPA PGLAAMLKMV
HSSVAPGNGR RATGSSSPGG GDAADPVALD SDTETCPGSP QPEFPSSASP GGGSPAPRVR
SISISSSSSS SSSMDEDDQA DGAGASSSSS SSSDDSDSDE GGEEETPRPR HSQNAAKTPS
AAGSPGPSSG GDRPAAGAAT PKSCRSGAAS PGAPAPAPAS APAPSRPGGG LLPPGARILE
YLEGVREANL AKTLERPEPP AGMASPPGRS PHRLPKDQRP KSALAGASKR KRANPRPRPQ
TQTQAPAEEA PQTAVWDLLD MNSSQATGAA AAAASAPAAA SCAPGVYQRE PLLTPSGDPW
PGSDPPPMGR VRYGGTGDSR DGLWDDPEIV LAASRYAEAQ APVPVFVPEM GDSTKQYNAL
VRMVFESREA MSWLQNSKLS GQDQNLAQFC QKFIHAPRGH GSFITGSVAN PLPHIGDAMA
AGNALWALPH AAASVAMSRR YDRTQKSFIL QSLRRAYADM AYPRDEAGRP DSLAAVAGCP
AQAAAAAASQ QQPEAPAPSV RVREAYTRVC AALGPRRKAA AAAAAPGTRA PRPSAFRLRE
LGDACVLACQ AVFEALLRLR GGASAVPGLD PSEIPSPACP PEALCSNPAG LETAALSLYE
LRDLVERARL LGDSDPTHRL GSDELRLAVR AVLVVARTVA PLVRYNAEGA RARASAWTVT
QAVFSIPSLV GGMLGEAVSL LAPPTRSQQP SSSSPGGEPF SGSAAAEGSL QTLPPLWPTV
PGKQSATVPS SHSQSPQHSQ SGGGAGATTA TCCRATQTNA RSRGQQHQPQ KARSPQAAAS
PAHLSQEAMP GSSSDDRAIH GRPRGKSGKR RSEPLEPAAQ AGASASFSSS ARGYDPSGPV
DSPPAPKRRV ATPGHQAPRA LGPMPAEGPD RRGGFRRVPR GDCHTPRPSD AACAAYCPPE
LVAELIDNQL FPEAWRPALT FDPQALATIA ARCSGPPARD GARLGELAAS GPLRRRAAWM
HQIPDPEDVK VVVLYSPLQD EDLLGGLPAS RPGGSRREPL WSDLKGGLSA LLAALGNRIL
TKRSHAWAGN WTGAPDVSAL NAQGVLLLST GDLAFTGCVE YLCLRLGSAR RKLLVLDAVS
TEDWPQDGPA ISQYHIYMRA ALTPRVACAV RWPGERHLSR AVLTSSTLFG PGLFARAEAA
FARLYPDSAP LRLCRSSNVA YTVDTRAGER TRVPLAPREY RQRVLPDYDG CKDMRAQAEG
LGFHDPDFEE GAAQSHRAAN RWGLGAWLRP VYLACGRRGA GAVEPSELLI PELLSEFCRV
ALLEPDAEAE PLVLPITEAP RRRAPRVDWE PGFGSRSTSV LHMGATELCL PEPDDELEID
GAGDVELVVE HPGPSPGVAQ ALRRAPIKIE VVSDDEDGGD WCNPYLS
