ID   ICP4_GAHVG              Reviewed;        1415 AA.
AC   Q02362;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   02-JUN-2021, entry version 78.
DE   RecName: Full=Major viral transcription factor ICP4 homolog;
DE   AltName: Full=Immediate-early protein IE175;
GN   Name=ICP4;
OS   Gallid herpesvirus 2 (strain GA) (GaHV-2) (Marek's disease herpesvirus type
OS   1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10388;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1322594; DOI=10.1016/0042-6822(92)90589-h;
RA   Anderson A.S., Francesconi A., Morgan R.W.;
RT   "Complete nucleotide sequence of the Marek's disease virus ICP4 gene.";
RL   Virology 189:657-667(1992).
CC   -!- FUNCTION: This IE protein is a multifunctional protein capable of
CC       migrating to the nucleus, binding to DNA, trans-activating other viral
CC       genes, and autoregulating its own synthesis. It is required for the
CC       switch from immediate-early to early mode of gene expression.
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- PTM: A long stretch of serine residues may be a major site of
CC       phosphorylation.
CC   -!- SIMILARITY: Belongs to the herpesviridae ICP4 family. {ECO:0000305}.
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DR   EMBL; M75729; AAA46111.1; -; Genomic_DNA.
DR   SMR; Q02362; -.
DR   PRIDE; Q02362; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039695; P:DNA-templated viral transcription; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005205; Herpes_ICP4_C.
DR   InterPro; IPR005206; Herpes_ICP4_N.
DR   Pfam; PF03585; Herpes_ICP4_C; 1.
DR   Pfam; PF03584; Herpes_ICP4_N; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Early protein; Host nucleus; Phosphoprotein;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..1415
FT                   /note="Major viral transcription factor ICP4 homolog"
FT                   /id="PRO_0000115819"
FT   REGION          48..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          454..480
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          691..935
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1371..1415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..239
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        720..735
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        766..802
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        817..844
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        852..868
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        897..931
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1415 AA;  154937 MW;  C0846F7BEF4D1126 CRC64;
     MVELGFPAYG PAIEKRVRPL YKALCDWRAA VTLAARRRFQ QLRCNANMDD DGQPMFPPLP
     VPDWNNPSTD WRPSPPRSGP KKDFCGDLPA PLTSGPRLTT PSSGRMSELP HTTSSPRSSP
     RPRGPETSPS NEHIIISPPR NPPSNTTHRN VGHVSRSPSS SSSSSSSSSP SSSSLIVLSS
     PSSSRSPSPS PPRPRADSSS RPRRGRGSNR GGRSGPQSKG RKASPRTRKL EDEDYLPQET
     ANRRGGGRPR GRPPKSGRAV QRNDIQVTSS SGLADTSPYD LCGSVWWEVP LPPPGRCWFG
     GLGGHRQALT DSPEIVEAIH RFNTSHGPVP VYVEEMKDYA KQYDALVNSL FHKSMKVNPL
     NWMHHGKLSP ADAALNHIYV QKFQSSYDSP GAAVTGTVNR CIPHIAGAMK ERKLLWAFPH
     IAASIAMTRR YCKDQKTFLF RSLKKAYASM AFPDNSSETE KGISSKPSTS PSVLITTSTQ
     TTASPHAPKI DVTAIHGRVY QSVVDLSRCL ADGSLDDPEF SFAGCTRPDC CVEEFDAARP
     LEELADACVL ACDSVVAALL CGPDGPHRVA KMLSFYDSRI TPHVPDSQQW EKCRILLVSW
     YNELSDLRAA VYGAYGNTPT SQHLDERALA ARVVSLIAET IGPLVRQDPD RAWVRMGSRD
     ITSLLLRDWR GTNDGDPGLV KAKHLRRTAE LLNDGRSSKG TYGVFAPPRR PDQLFRGPGR
     PRRSTSSSQS ASDKSPIKST HRHTSDPIPI STPRPERDPA GTPHENTMSG PVQPAANGHS
     CSSTPTPAKK GNKTSSDTIS LKDPTKTRIK ASAKAQTDET LPETSTAHPS AMDQSSSLER
     KTLYTGPAVS SKERRRSAQS STPSDIGGVS RKRKSAPEQY KQGLQTPLPM PEPSVGQTLL
     DPTTTTHDIL SSSLPNRSCS SSPSPSKRPY HPSCYSPTDI MTGALVGPRG RQDRAAFRQF
     PVGTVIGQTP PQSVLNAYCP NGAFVELVEF ARIPEPWQEV LRYSPEAMAD IARVANALPG
     KYNSNEIITS AASEAFHTAT SKLRARTAWM RYQQESPDDV SIVVLYSPLP GEHLFCVPAP
     DTPPGGLKFD NKRGGLSFLL AAFSNRLCLP KSSAWAGRWK AAPDISPLTR MGVLFLSTED
     LGYQGAVEYL QRQCMKRKKK LIIMDTVEDR YRLPNGPCII EEATRYMKCI ISPRSQCCVR
     WPGLRDFGTT IITSRDVVGP LTLMDLEQYY YCEIGIEDST INLCCTGNVR YTVETRLEDV
     SCVPTTPLFY FAAVKHVRPD FLCGETYSNR AARKWGLCAP LRPIYVIESK MNAIVSPSFL
     HPTARNLCRS VILPPDPEAR PVVVHIPEGT CSALAEDMVA SIRSSCITWG QHEEGGPETT
     AQENSDIRAM KVRPPTKPPY MSPLNIGNRD TTFTD