ID   ICP4_GAHVM              Reviewed;        2321 AA.
AC   Q9DGT6;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   02-JUN-2021, entry version 75.
DE   RecName: Full=Major viral transcription factor ICP4 homolog;
DE   AltName: Full=Immediate-early protein IE175;
GN   Name=MDV084; Synonyms=MDV100;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- FUNCTION: This IE protein is a multifunctional protein capable of
CC       migrating to the nucleus, binding to DNA, trans-activating other viral
CC       genes, and autoregulating its own synthesis. It is required for the
CC       switch from immediate-early to early mode of gene expression (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- PTM: A long stretch of serine residues may be a major site of
CC       phosphorylation. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae ICP4 family. {ECO:0000305}.
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DR   EMBL; AF243438; AAG14273.1; -; Genomic_DNA.
DR   EMBL; AF243438; AAG14284.1; -; Genomic_DNA.
DR   RefSeq; YP_001034000.1; NC_002229.3.
DR   RefSeq; YP_001034018.1; NC_002229.3.
DR   SMR; Q9DGT6; -.
DR   PRIDE; Q9DGT6; -.
DR   GeneID; 4811466; -.
DR   GeneID; 4811547; -.
DR   KEGG; vg:4811466; -.
DR   KEGG; vg:4811547; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039695; P:DNA-templated viral transcription; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005205; Herpes_ICP4_C.
DR   InterPro; IPR005206; Herpes_ICP4_N.
DR   Pfam; PF03585; Herpes_ICP4_C; 1.
DR   Pfam; PF03584; Herpes_ICP4_N; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Early protein; Host nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..2321
FT                   /note="Major viral transcription factor ICP4 homolog"
FT                   /id="PRO_0000406502"
FT   REGION          19..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          296..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          350..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          954..1180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1360..1392
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1597..1841
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2277..2321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..180
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..329
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..367
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        368..385
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        386..418
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1001..1089
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1130..1145
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1626..1641
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1672..1708
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1723..1750
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1758..1774
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1803..1837
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2321 AA;  252962 MW;  EF130EB0C4503003 CRC64;
     MDNPPDFDSL LAAFDEDVGI FPHTPATPGD PYQGVSLQTP CVPVPSLAGQ SGTYRPHSSY
     HGQRSLSSGP VPAAHSPRSG RPGQHSTSNG VAAAAPPAAT RAVCDTAGPT TDTSSNRPGG
     RNSSNGADES GESSSDRSPS YSPCDSYCDP DRVSSYRSSV DGSPESGDIE SASGSGGTSS
     PPLLEILAAD FGEDTKALDP DYYLRADPRF KAYFYGMDEI SPTTSEDIDE LLVLLSPQSV
     NRASERQLAD TAASALRAPS PVFWSAFDSR YPHLAPANQS NSDPLCPETS TASAQILHTN
     SPTPPTSTSP APIPSPTQPP ACLPSPAPIS SPVQPPALLP LIFSPITPVE FIQPQSPPSP
     PQAPSPPAHS SSSCSPSHLA PSPLSSSPLS SPPQLSPAPV SPPSSPPPLS PGELAPSPDP
     PRHSISSQPQ SCPVPSLGRS ADFRREVAAP RVRGAGFRYV YRLSTSVAIP SPPREEVELI
     KHLPGSYAKL WLHDPDGFSP LPEELKRAGR QNMRSFLLTL PDTHRCSAYW DCLATEALLR
     EILPPPHTSS PQKCPRIIEL PREPPLLDGD YKPFDWDVEC NYAPPLPDFP EPICELSKDW
     VGCKIWLFSH CSRLVLSVLD DALHSESHEN VLGSRGCGWG PRSECPVPPP GMVTLPSCVW
     EAAARLPTPA LQIPKYAYII SAFLRFLGLR VTPEFVFKVP RLSYRLLDRL RCLRRVQYMA
     YILTQDFSYQ LQAAQGLPCF PACAPPPGAG TPLDEDWYGI PATRCPTIPD RLRHCGQFYS
     DNYCPVLTEI TWVDGRDGST NPWTGLAWKD FKCLHYRYLF YNVRKGFVMA PENYLTENSV
     IPGCEVTFEM PQPSTTLPPA LSAAIREARV ELRNRNNIQT GDGSESGEHR DSKVSYAFMV
     QQLAIAMVEL GFPAYGPAIE KRVRPLYKAL CDWRAAVTLA ARRRFQQLRC NANMDDDGQP
     MFPPLPVPDW NNPSTDWRPS PPRSGPKKDF CGDLPAPLTS GPRLTTPSSG RMSELPHTTS
     SPRSSPRPRG PETSPSNEHI IISPPRNPPS NTTHRNVGHV SRSPSSSSSS SSSSSPSSSS
     LIVPSSPSSS RSPSPSPPRP RADCSSRPRR GRGSNRGGRS GPQSKGRKTS PRTRKLEDED
     YLPQETANRR GGGRPRGRPP KSGRAVQRND IQVTSSSGLA DTSPYDLCGS VWWEVPLPPP
     GRCWFGGLGG HRQALTDSPE IVEAIHRFNT SHGPVPVYVE EMKDYAKQYD ALVNSLFHKS
     MKVNPLNWMH HGKLSPADAA LNHIYVQKFQ SSYDSPGAAV TGTVNRCIPH IAGAMKERKL
     LWAFPHIAAS IAMTRRYCKD QKTFLFRSLK KAYASMAFPD NSSETEKGIS SKPSTSPSVL
     ITTSTQTTAP PHAPKIDVTA IHGRVYQSVV DLSRCLADGS LDDPEFSFAG CTRPDCLVEE
     FDAARPLEEL ADACVLACDS VVAALLCGPD GPHRVAKMLS FYDSRITPHV PDLQQWEKCR
     ILLVSWYHEL SDLRAAVYGA YGNTPTSQHL DERALAARVV SLIAETIGPL VRQDPDRAWV
     RMGSRDITSL LLRDWRGTND GDPGLVKAKH LRRTAELLND GRSSKGTYGV FAPPRRPDQL
     FRGPGRPRRS TSSSQSASDK SPIKSTHRHT SDPIPISTPR PERDPAGTPH ENTMSGPVQP
     AANGHSCSST PTPAKKGNKT SSDTISLKDP TKTRIKASAK AQTDETLPET STAHPSAMDQ
     SSSLERKNLY TGPAVSSKER RRSAQSSTPS DIGGVSRKRK SAPEQYKQGL QTPLPMPEPS
     VGQTLLDPTT TTHDILSSSL PNRSCSSSPS PSKRPYHPSC YSPTDIMTGA LVGPRGRQDR
     AAFRQFPVGT VIGQTPPQSV LNAYCPNGAF VELVEFARIP EPWQEVLRYS PEAMADIARV
     ANALPGKYNS NEIITSAASE AFHTATSKLR ARTAWMRYQQ ESPDDVSIVV LYSPLPGEHL
     FCVPAPDTPP GGLKFDNKRG GLSFLLAAFS NRLCLPKSSA WAGRWKAAPD ISPLTRMGVL
     FLSTEDLGYQ GAVEYLQRQC MKRKKKLIIM DTVEDRYRLP NGPCIIEEAT RYMKCIISPR
     SQCCVRWPGL LDFGTTIITS RDVVGPLTLM DLEQYYYCEI GIEDSTINLC CTGNVRYTVE
     TRLEDVSCVP TTPLFYFAAV KHVRPDFLCG ETYSNRAARK WGLCAPLRPI YVIESKMNAI
     VSPSFLHPTA RNLCRSVILP PDPEARPVVV HIPEGTCSAL AEDMVASIRS SCITWGQHEE
     GGPETTAQEN SDIRAMKVRP PTKPPYMSPL NIGNRDTTFT D